A nuclear singlet lifetime of more than one hour in room-temperature solution

Gabriele Stevanato; Joseph T. Hill-Cousins; Soumya Singha Roy; Lynda J. Brown; Richard C D Brown; Giuseppe Pileio; Malcolm H. Levitt

doi:10.1002/anie.201411978

A nuclear singlet lifetime of more than one hour in room-temperature solution

Gabriele Stevanato, Joseph T. Hill-Cousins, Soumya Singha Roy, Lynda J. Brown, Richard C D Brown, Giuseppe Pileio, Malcolm H. Levitt

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T₁ for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T₁ by large factors. Here we demonstrate a nuclear long-lived state comprising two ¹³C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T₁. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a ¹³C₂-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.

Original language	English
Pages (from-to)	3740-3743
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	54
Issue number	12
DOIs	https://doi.org/10.1002/anie.201411978
Publication status	Published - 16 Mar 2015

Keywords

long-lived spin states
NMR spectroscopy
nuclear spin relaxation
singlet states

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title = "A nuclear singlet lifetime of more than one hour in room-temperature solution",

abstract = "Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.",

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author = "Gabriele Stevanato and Hill-Cousins, {Joseph T.} and Roy, {Soumya Singha} and Brown, {Lynda J.} and Brown, {Richard C D} and Giuseppe Pileio and Levitt, {Malcolm H.}",

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T1 - A nuclear singlet lifetime of more than one hour in room-temperature solution

AU - Stevanato, Gabriele

AU - Hill-Cousins, Joseph T.

AU - Roy, Soumya Singha

AU - Brown, Lynda J.

AU - Brown, Richard C D

AU - Pileio, Giuseppe

AU - Levitt, Malcolm H.

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N2 - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.

AB - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.

KW - long-lived spin states

KW - NMR spectroscopy

KW - nuclear spin relaxation

KW - singlet states

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A nuclear singlet lifetime of more than one hour in room-temperature solution

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Keywords

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