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A nuclear singlet lifetime of more than one hour in room-temperature solution

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A nuclear singlet lifetime of more than one hour in room-temperature solution. / Stevanato, Gabriele; Hill-Cousins, Joseph T.; Roy, Soumya Singha; Brown, Lynda J.; Brown, Richard C D; Pileio, Giuseppe; Levitt, Malcolm H.

In: Angewandte Chemie International Edition, Vol. 54, No. 12, 16.03.2015, p. 3740-3743.

Research output: Contribution to journalArticlepeer-review

Harvard

Stevanato, G, Hill-Cousins, JT, Roy, SS, Brown, LJ, Brown, RCD, Pileio, G & Levitt, MH 2015, 'A nuclear singlet lifetime of more than one hour in room-temperature solution', Angewandte Chemie International Edition, vol. 54, no. 12, pp. 3740-3743. https://doi.org/10.1002/anie.201411978

APA

Stevanato, G., Hill-Cousins, J. T., Roy, S. S., Brown, L. J., Brown, R. C. D., Pileio, G., & Levitt, M. H. (2015). A nuclear singlet lifetime of more than one hour in room-temperature solution. Angewandte Chemie International Edition, 54(12), 3740-3743. https://doi.org/10.1002/anie.201411978

Vancouver

Stevanato G, Hill-Cousins JT, Roy SS, Brown LJ, Brown RCD, Pileio G et al. A nuclear singlet lifetime of more than one hour in room-temperature solution. Angewandte Chemie International Edition. 2015 Mar 16;54(12):3740-3743. https://doi.org/10.1002/anie.201411978

Author

Stevanato, Gabriele ; Hill-Cousins, Joseph T. ; Roy, Soumya Singha ; Brown, Lynda J. ; Brown, Richard C D ; Pileio, Giuseppe ; Levitt, Malcolm H. / A nuclear singlet lifetime of more than one hour in room-temperature solution. In: Angewandte Chemie International Edition. 2015 ; Vol. 54, No. 12. pp. 3740-3743.

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@article{4eb9538c1e64437bac5500006e1bcfd1,
title = "A nuclear singlet lifetime of more than one hour in room-temperature solution",
abstract = "Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.",
keywords = "long-lived spin states, NMR spectroscopy, nuclear spin relaxation, singlet states",
author = "Gabriele Stevanato and Hill-Cousins, {Joseph T.} and Roy, {Soumya Singha} and Brown, {Lynda J.} and Brown, {Richard C D} and Giuseppe Pileio and Levitt, {Malcolm H.}",
year = "2015",
month = mar,
day = "16",
doi = "10.1002/anie.201411978",
language = "English",
volume = "54",
pages = "3740--3743",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A nuclear singlet lifetime of more than one hour in room-temperature solution

AU - Stevanato, Gabriele

AU - Hill-Cousins, Joseph T.

AU - Roy, Soumya Singha

AU - Brown, Lynda J.

AU - Brown, Richard C D

AU - Pileio, Giuseppe

AU - Levitt, Malcolm H.

PY - 2015/3/16

Y1 - 2015/3/16

N2 - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.

AB - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with numerous applications in almost all branches of science. However, until recently, NMR methodology was limited by the time constant T1 for the decay of nuclear spin magnetization through contact with the thermal molecular environment. Long-lived states, which are correlated quantum states of multiple nuclei, have decay time constants that may exceed T1 by large factors. Here we demonstrate a nuclear long-lived state comprising two 13C nuclei with a lifetime exceeding one hour in room-temperature solution, which is around 50 times longer than T1. This behavior is well-predicted by a combination of quantum theory, molecular dynamics, and quantum chemistry. Such ultra-long-lived states are expected to be useful for the transport and application of nuclear hyperpolarization, which leads to NMR and MRI signals enhanced by up to five orders of magnitude. A long-lived nuclear singlet: A molecular system based on a 13C2-labelled naphthalene core has been designed to support long-lived nuclear singlet order in solution. A nuclear singlet lifetime exceeding one hour has been achieved in room-temperature solution.

KW - long-lived spin states

KW - NMR spectroscopy

KW - nuclear spin relaxation

KW - singlet states

UR - http://www.scopus.com/inward/record.url?scp=84924410427&partnerID=8YFLogxK

U2 - 10.1002/anie.201411978

DO - 10.1002/anie.201411978

M3 - Article

VL - 54

SP - 3740

EP - 3743

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 12

ER -