A one-pot oxidation-imine formation-reduction route from alcohols to amines using manganese dioxide-sodium borohydride: the synthesis of naftifine

H Kanno, R J K Taylor

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A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine. (C) 2002 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)7337-7340
Number of pages4
JournalTetrahedron Letters
Issue number41
Publication statusPublished - 7 Oct 2002


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