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From the same journal

A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones

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A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones. / Lloyd, Matthew G; Taylor, Richard J K; Unsworth, William P.

In: Organic Letters, Vol. 16, No. 10, 2014, p. 2772-2775.

Research output: Contribution to journalArticlepeer-review

Harvard

Lloyd, MG, Taylor, RJK & Unsworth, WP 2014, 'A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones', Organic Letters, vol. 16, no. 10, pp. 2772-2775. https://doi.org/10.1021/ol501092m

APA

Lloyd, M. G., Taylor, R. J. K., & Unsworth, W. P. (2014). A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones. Organic Letters, 16(10), 2772-2775. https://doi.org/10.1021/ol501092m

Vancouver

Lloyd MG, Taylor RJK, Unsworth WP. A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones. Organic Letters. 2014;16(10):2772-2775. https://doi.org/10.1021/ol501092m

Author

Lloyd, Matthew G ; Taylor, Richard J K ; Unsworth, William P. / A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones. In: Organic Letters. 2014 ; Vol. 16, No. 10. pp. 2772-2775.

Bibtex - Download

@article{162a66386bee4a5f8ab4e66a355d65eb,
title = "A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones",
abstract = "A one-pot C-H insertion/olefination sequence for the conversion of α-diazo-α-(dialkoxyphosphoryl)acetates into α-alkylidene-γ-butyrolactones is reported. The key C-H insertion process is achieved using a catalytic amount of a dirhodium carboxylate catalyst, using operationally simple conditions. The size and electronic properties of the attached substituents were found to influence the regio- and diastereoselectivity of the process. The utility of the process is demonstrated by the synthesis of a known Staphylococcus aureus (MRSA) virulence inhibitor.",
author = "Lloyd, {Matthew G} and Taylor, {Richard J K} and Unsworth, {William P}",
year = "2014",
doi = "10.1021/ol501092m",
language = "English",
volume = "16",
pages = "2772--2775",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "10",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A One-Pot C-H Insertion/Olefination Sequence for the Formation of α-Alkylidene-γ-butyrolactones

AU - Lloyd, Matthew G

AU - Taylor, Richard J K

AU - Unsworth, William P

PY - 2014

Y1 - 2014

N2 - A one-pot C-H insertion/olefination sequence for the conversion of α-diazo-α-(dialkoxyphosphoryl)acetates into α-alkylidene-γ-butyrolactones is reported. The key C-H insertion process is achieved using a catalytic amount of a dirhodium carboxylate catalyst, using operationally simple conditions. The size and electronic properties of the attached substituents were found to influence the regio- and diastereoselectivity of the process. The utility of the process is demonstrated by the synthesis of a known Staphylococcus aureus (MRSA) virulence inhibitor.

AB - A one-pot C-H insertion/olefination sequence for the conversion of α-diazo-α-(dialkoxyphosphoryl)acetates into α-alkylidene-γ-butyrolactones is reported. The key C-H insertion process is achieved using a catalytic amount of a dirhodium carboxylate catalyst, using operationally simple conditions. The size and electronic properties of the attached substituents were found to influence the regio- and diastereoselectivity of the process. The utility of the process is demonstrated by the synthesis of a known Staphylococcus aureus (MRSA) virulence inhibitor.

U2 - 10.1021/ol501092m

DO - 10.1021/ol501092m

M3 - Article

C2 - 24788001

VL - 16

SP - 2772

EP - 2775

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 10

ER -