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A one-pot oxidation-imine formation-reduction route from alcohols to amines using manganese dioxide-sodium borohydride: the synthesis of naftifine

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Publication details

JournalTetrahedron Letters
DatePublished - 7 Oct 2002
Issue number41
Number of pages4
Pages (from-to)7337-7340
Original languageEnglish


A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine. (C) 2002 Elsevier Science Ltd. All rights reserved.

    Research areas

  • ACID

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