A panel of subunit-selective activity-based proteasome probes

Martijn Verdoes, Lianne I. Willems, Wouter A. Van Der Linden, Boudewijn A. Duivenvoorden, Gijsbert A. Van Der Marel, Bogdan I. Florea, Alexei F. Kisselev, Herman S. Overkleeft

Research output: Contribution to journalArticlepeer-review


Mammals express seven different catalytically active proteasome subunits. In order to determine the roles of the different proteolytically active subunits in antigen presentation and other cellular processes, highly specific inhibitors and activity-based probes that selectively target specific active sites are needed. In this work we present the development of fluorescent activity-based probes that selectively target the β1 and β5 sites of the constitutive proteasome.

Original languageEnglish
Pages (from-to)2719-2727
Number of pages9
JournalOrganic and Biomolecular Chemistry
Issue number12
Publication statusPublished - 21 Jun 2010

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