A panel of subunit-selective activity-based proteasome probes

TY - JOUR

T1 - A panel of subunit-selective activity-based proteasome probes

AU - Verdoes, Martijn

AU - Willems, Lianne I.

AU - Van Der Linden, Wouter A.

AU - Duivenvoorden, Boudewijn A.

AU - Van Der Marel, Gijsbert A.

AU - Florea, Bogdan I.

AU - Kisselev, Alexei F.

AU - Overkleeft, Herman S.

PY - 2010/6/21

Y1 - 2010/6/21

N2 - Mammals express seven different catalytically active proteasome subunits. In order to determine the roles of the different proteolytically active subunits in antigen presentation and other cellular processes, highly specific inhibitors and activity-based probes that selectively target specific active sites are needed. In this work we present the development of fluorescent activity-based probes that selectively target the β1 and β5 sites of the constitutive proteasome.

AB - Mammals express seven different catalytically active proteasome subunits. In order to determine the roles of the different proteolytically active subunits in antigen presentation and other cellular processes, highly specific inhibitors and activity-based probes that selectively target specific active sites are needed. In this work we present the development of fluorescent activity-based probes that selectively target the β1 and β5 sites of the constitutive proteasome.

UR - http://www.scopus.com/inward/record.url?scp=77953194791&partnerID=8YFLogxK

U2 - 10.1039/c001036g

DO - 10.1039/c001036g

M3 - Article

C2 - 20449511

AN - SCOPUS:77953194791

VL - 8

SP - 2719

EP - 2727

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 12

ER -