A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors

L. Kheifets; A. Ahlbom; C. M. Crespi; M. Feychting; C. Johansen; J. Monroe; M. F. G. Murphy; S. Oksuzyan; S. Preston-Martin; E. Roman; T. Saito; D. Savitz; J. Schuez; J. Simpson; J. Swanson; T. Tynes; P. Verkasalo; G. Mezei

doi:10.1093/aje/kwq181

A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors

L. Kheifets, A. Ahlbom, C. M. Crespi, M. Feychting, C. Johansen, J. Monroe, M. F. G. Murphy, S. Oksuzyan, S. Preston-Martin, E. Roman, T. Saito, D. Savitz, J. Schuez, J. Simpson, J. Swanson, T. Tynes, P. Verkasalo, G. Mezei

Health Sciences

Research output: Contribution to journal › Literature review › peer-review

Abstract

Pooled analyses may provide etiologic insight about associations between exposure and disease. In contrast to childhood leukemia, no pooled analyses of childhood brain tumors and exposure to extremely low-frequency magnetic fields (ELF-MFs) have been conducted. The authors carried out a pooled analysis based on primary data (1960-2001) from 10 studies of ELF-MF exposure and childhood brain tumors to assess whether the combined results, adjusted for potential confounding, indicated an association. The odds ratios for childhood brain tumors in ELF-MF exposure categories of 0.1-<0.2 mu T, 0.2-<0.4 mu T, and >= 0.4 mu T were 0.95 (95% confidence interval: 0.65, 1.41), 0.70 (95% CI: 0.40, 1.22), and 1.14 (95% CI: 0.61, 2.13), respectively, in comparison with exposure of <0.1 mu T. Other analyses employing alternate cutpoints, further adjustment for confounders, exclusion of particular studies, stratification by type of measurement or type of residence, and a nonparametric estimate of the exposure-response relation did not reveal consistent evidence of increased childhood brain tumor risk associated with ELF-MF exposure. These results provide little evidence for an association between ELF-MF exposure and childhood brain tumors.

Original language	English
Pages (from-to)	752-761
Number of pages	10
Journal	American Journal of Epidemiology
Volume	172
Issue number	7
DOIs	https://doi.org/10.1093/aje/kwq181
Publication status	Published - 1 Oct 2010

Keywords

brain neoplasms
child
electromagnetic fields
meta-analysis
VOLTAGE POWER-LINES
ELECTROMAGNETIC-FIELDS
CANCER
EXPOSURE
RISK
LEUKEMIA
CHILDREN
CONFIGURATIONS

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Kheifets, L., Ahlbom, A., Crespi, C. M., Feychting, M., Johansen, C., Monroe, J., Murphy, M. F. G., Oksuzyan, S., Preston-Martin, S., Roman, E., Saito, T., Savitz, D., Schuez, J., Simpson, J., Swanson, J., Tynes, T., Verkasalo, P., & Mezei, G. (2010). A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors. American Journal of Epidemiology, 172(7), 752-761. https://doi.org/10.1093/aje/kwq181

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title = "A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors",

abstract = "Pooled analyses may provide etiologic insight about associations between exposure and disease. In contrast to childhood leukemia, no pooled analyses of childhood brain tumors and exposure to extremely low-frequency magnetic fields (ELF-MFs) have been conducted. The authors carried out a pooled analysis based on primary data (1960-2001) from 10 studies of ELF-MF exposure and childhood brain tumors to assess whether the combined results, adjusted for potential confounding, indicated an association. The odds ratios for childhood brain tumors in ELF-MF exposure categories of 0.1-<0.2 mu T, 0.2-<0.4 mu T, and >= 0.4 mu T were 0.95 (95% confidence interval: 0.65, 1.41), 0.70 (95% CI: 0.40, 1.22), and 1.14 (95% CI: 0.61, 2.13), respectively, in comparison with exposure of <0.1 mu T. Other analyses employing alternate cutpoints, further adjustment for confounders, exclusion of particular studies, stratification by type of measurement or type of residence, and a nonparametric estimate of the exposure-response relation did not reveal consistent evidence of increased childhood brain tumor risk associated with ELF-MF exposure. These results provide little evidence for an association between ELF-MF exposure and childhood brain tumors.",

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author = "L. Kheifets and A. Ahlbom and Crespi, {C. M.} and M. Feychting and C. Johansen and J. Monroe and Murphy, {M. F. G.} and S. Oksuzyan and S. Preston-Martin and E. Roman and T. Saito and D. Savitz and J. Schuez and J. Simpson and J. Swanson and T. Tynes and P. Verkasalo and G. Mezei",

year = "2010",

month = oct,

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Kheifets, L, Ahlbom, A, Crespi, CM, Feychting, M, Johansen, C, Monroe, J, Murphy, MFG, Oksuzyan, S, Preston-Martin, S, Roman, E, Saito, T, Savitz, D, Schuez, J, Simpson, J, Swanson, J, Tynes, T, Verkasalo, P & Mezei, G 2010, 'A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors', American Journal of Epidemiology, vol. 172, no. 7, pp. 752-761. https://doi.org/10.1093/aje/kwq181

TY - JOUR

T1 - A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors

AU - Kheifets, L.

AU - Ahlbom, A.

AU - Crespi, C. M.

AU - Feychting, M.

AU - Johansen, C.

AU - Monroe, J.

AU - Murphy, M. F. G.

AU - Oksuzyan, S.

AU - Preston-Martin, S.

AU - Roman, E.

AU - Saito, T.

AU - Savitz, D.

AU - Schuez, J.

AU - Simpson, J.

AU - Swanson, J.

AU - Tynes, T.

AU - Verkasalo, P.

AU - Mezei, G.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Pooled analyses may provide etiologic insight about associations between exposure and disease. In contrast to childhood leukemia, no pooled analyses of childhood brain tumors and exposure to extremely low-frequency magnetic fields (ELF-MFs) have been conducted. The authors carried out a pooled analysis based on primary data (1960-2001) from 10 studies of ELF-MF exposure and childhood brain tumors to assess whether the combined results, adjusted for potential confounding, indicated an association. The odds ratios for childhood brain tumors in ELF-MF exposure categories of 0.1-<0.2 mu T, 0.2-<0.4 mu T, and >= 0.4 mu T were 0.95 (95% confidence interval: 0.65, 1.41), 0.70 (95% CI: 0.40, 1.22), and 1.14 (95% CI: 0.61, 2.13), respectively, in comparison with exposure of <0.1 mu T. Other analyses employing alternate cutpoints, further adjustment for confounders, exclusion of particular studies, stratification by type of measurement or type of residence, and a nonparametric estimate of the exposure-response relation did not reveal consistent evidence of increased childhood brain tumor risk associated with ELF-MF exposure. These results provide little evidence for an association between ELF-MF exposure and childhood brain tumors.

AB - Pooled analyses may provide etiologic insight about associations between exposure and disease. In contrast to childhood leukemia, no pooled analyses of childhood brain tumors and exposure to extremely low-frequency magnetic fields (ELF-MFs) have been conducted. The authors carried out a pooled analysis based on primary data (1960-2001) from 10 studies of ELF-MF exposure and childhood brain tumors to assess whether the combined results, adjusted for potential confounding, indicated an association. The odds ratios for childhood brain tumors in ELF-MF exposure categories of 0.1-<0.2 mu T, 0.2-<0.4 mu T, and >= 0.4 mu T were 0.95 (95% confidence interval: 0.65, 1.41), 0.70 (95% CI: 0.40, 1.22), and 1.14 (95% CI: 0.61, 2.13), respectively, in comparison with exposure of <0.1 mu T. Other analyses employing alternate cutpoints, further adjustment for confounders, exclusion of particular studies, stratification by type of measurement or type of residence, and a nonparametric estimate of the exposure-response relation did not reveal consistent evidence of increased childhood brain tumor risk associated with ELF-MF exposure. These results provide little evidence for an association between ELF-MF exposure and childhood brain tumors.

KW - brain neoplasms

KW - child

KW - electromagnetic fields

KW - meta-analysis

KW - VOLTAGE POWER-LINES

KW - ELECTROMAGNETIC-FIELDS

KW - CANCER

KW - EXPOSURE

KW - RISK

KW - LEUKEMIA

KW - CHILDREN

KW - CONFIGURATIONS

UR - http://www.scopus.com/inward/record.url?scp=77957308282&partnerID=8YFLogxK

U2 - 10.1093/aje/kwq181

DO - 10.1093/aje/kwq181

M3 - Literature review

SN - 0002-9262

VL - 172

SP - 752

EP - 761

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

IS - 7

ER -

A Pooled Analysis of Extremely Low-Frequency Magnetic Fields and Childhood Brain Tumors

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Keywords

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