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A radical approach to debenzylation of amides

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Publication details

JournalTetrahedron Letters
DatePublished - 15 Jan 1998
Issue number3-4
Number of pages2
Pages (from-to)331-332
Original languageEnglish


The deprotection of N-benzylamides can be achieved under neutral conditions by reaction with N-bromosuccinimide in boiling chlorobenzene or ethyl acetate. Good to excellent yields are obtained using either acyclic or cyclic amides. (C) 1997 Elsevier Science Ltd. All rights reserved.

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