A radical approach to debenzylation of amides

S R  Baker; A F  Parsons; M  Wilson

A radical approach to debenzylation of amides

S R Baker, A F Parsons, M Wilson

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The deprotection of N-benzylamides can be achieved under neutral conditions by reaction with N-bromosuccinimide in boiling chlorobenzene or ethyl acetate. Good to excellent yields are obtained using either acyclic or cyclic amides. (C) 1997 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	331-332
Number of pages	2
Journal	Tetrahedron Letters
Volume	39
Issue number	3-4
Publication status	Published - 15 Jan 1998

Cite this

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title = "A radical approach to debenzylation of amides",

abstract = "The deprotection of N-benzylamides can be achieved under neutral conditions by reaction with N-bromosuccinimide in boiling chlorobenzene or ethyl acetate. Good to excellent yields are obtained using either acyclic or cyclic amides. (C) 1997 Elsevier Science Ltd. All rights reserved.",

author = "Baker, {S R} and Parsons, {A F} and M Wilson",

year = "1998",

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pages = "331--332",

journal = "Tetrahedron Letters",

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T1 - A radical approach to debenzylation of amides

AU - Baker, S R

AU - Parsons, A F

AU - Wilson, M

PY - 1998/1/15

Y1 - 1998/1/15

N2 - The deprotection of N-benzylamides can be achieved under neutral conditions by reaction with N-bromosuccinimide in boiling chlorobenzene or ethyl acetate. Good to excellent yields are obtained using either acyclic or cyclic amides. (C) 1997 Elsevier Science Ltd. All rights reserved.

AB - The deprotection of N-benzylamides can be achieved under neutral conditions by reaction with N-bromosuccinimide in boiling chlorobenzene or ethyl acetate. Good to excellent yields are obtained using either acyclic or cyclic amides. (C) 1997 Elsevier Science Ltd. All rights reserved.

M3 - Article

SN - 0040-4039

VL - 39

SP - 331

EP - 332

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 3-4

ER -