A radical approach to N-desulfonylation

A F Parsons, R M Pettifer

Research output: Contribution to journalArticlepeer-review

Abstract

The deprotection of N-sulfonylated amides can be achieved under neutral conditions by reaction with tributyltin hydride. Good yields are obtained using N-benzoyl and related amides while the corresponding N-acetyl derivatives are inert under the same reaction conditions. The mechanistic implications of this are discussed.

Original languageEnglish
Pages (from-to)1667-1670
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number10
Publication statusPublished - 4 Mar 1996

Keywords

  • SULFONAMIDES
  • EFFICIENT

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