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A Ramberg-Backlund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

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JournalChemical Communications
DatePublished - 28 Apr 2007
Issue number16
Number of pages3
Pages (from-to)1617-1619
Original languageEnglish

Abstract

A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg-Backlund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg-Backlund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties.

    Research areas

  • ANTINEOPLASTIC AGENTS, RESVERATROL, TUBULIN, CYCLOOXYGENASE-2, CHEMISTRY, ANALOG

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