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A Ramberg-Bäcklund route to the stilbenoid anti-cancer agents combretastatin A-4 and DMU-212

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JournalChemical Communications
DateE-pub ahead of print - 20 Mar 2007
DatePublished (current) - 28 Apr 2007
Issue number16
Number of pages3
Pages (from-to)1617-9
Early online date20/03/07
Original languageEnglish

Abstract

A concise route to combretastatin A-4, a potent inhibitor of tubulin polymerisation, using a Ramberg-Bäcklund reaction to form the key (Z)-stilbene unit has been developed; this Ramberg-Bäcklund approach has also been extended to prepare the (E)-stilbene DMU-212, which also possesses interesting growth inhibitory properties.

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