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From the same journal

A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial

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A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER : ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial. / Duffy, Larisa; Bacon, Faye; Clarke, Caroline S; Donkor, Yvonne; Freemantle, Nick; Gilbody, Simon; Hunter, Rachael; Kendrick, Tony; Kessler, David; King, Michael; Lanham, Paul; Lewis, Gemma; Mangin, Dee; Marston, Louise; Moore, Michael; Nazareth, Irwin; Wiles, Nicola; Lewis, Glyn.

In: Trials, Vol. 20, No. 1, 319, 03.06.2019, p. 319.

Research output: Contribution to journalArticle

Harvard

Duffy, L, Bacon, F, Clarke, CS, Donkor, Y, Freemantle, N, Gilbody, S, Hunter, R, Kendrick, T, Kessler, D, King, M, Lanham, P, Lewis, G, Mangin, D, Marston, L, Moore, M, Nazareth, I, Wiles, N & Lewis, G 2019, 'A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial', Trials, vol. 20, no. 1, 319, pp. 319. https://doi.org/10.1186/s13063-019-3390-8

APA

Duffy, L., Bacon, F., Clarke, C. S., Donkor, Y., Freemantle, N., Gilbody, S., ... Lewis, G. (2019). A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial. Trials, 20(1), 319. [319]. https://doi.org/10.1186/s13063-019-3390-8

Vancouver

Duffy L, Bacon F, Clarke CS, Donkor Y, Freemantle N, Gilbody S et al. A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial. Trials. 2019 Jun 3;20(1):319. 319. https://doi.org/10.1186/s13063-019-3390-8

Author

Duffy, Larisa ; Bacon, Faye ; Clarke, Caroline S ; Donkor, Yvonne ; Freemantle, Nick ; Gilbody, Simon ; Hunter, Rachael ; Kendrick, Tony ; Kessler, David ; King, Michael ; Lanham, Paul ; Lewis, Gemma ; Mangin, Dee ; Marston, Louise ; Moore, Michael ; Nazareth, Irwin ; Wiles, Nicola ; Lewis, Glyn. / A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER : ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial. In: Trials. 2019 ; Vol. 20, No. 1. pp. 319.

Bibtex - Download

@article{8dc70adf2d784640ac0c820bf0f4dce5,
title = "A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial",
abstract = "BACKGROUND: Antidepressants are used both for treating acute episodes and for prophylaxis to prevent future episodes of depression, also called maintenance treatment. This article describes the protocol for a randomised controlled trial (ANTLER: ANTidepressants to prevent reLapse in dEpRession) to investigate the clinical effectiveness and cost-effectiveness in UK primary care of continuing on long-term maintenance antidepressants compared with a placebo in preventing relapse of depression in those who have taken antidepressants for more than 9 months and who are currently well enough to consider stopping maintenance treatment.METHODS/DESIGN: The ANTLER trial is an individually randomised, double-blind, placebo-controlled trial in which participants are randomised to remain on active medication or to take an identical placebo after a tapering period of 2 months. Eligible participants are those who: are between the ages of 18 and 74 years; have had at least two episodes of depression; and have been taking antidepressants for 9 months or more and are currently taking citalopram 20 mg, sertraline 100 mg, fluoxetine 20 mg or mirtazapine 30 mg but are well enough to consider stopping their medication. The participants will be followed up at 6, 12, 26, 39 and 52 weeks. The primary outcome will be the time in weeks to the beginning of the first episode of depression after randomisation. This will be measured using a retrospective version of the Clinical Interview Schedule-Revised administered at 12, 26, 39 and 52 weeks. Secondary outcomes will include depressive and anxiety symptoms, adverse effects, withdrawal symptoms, emotional processing tasks, quality of life and the resources and costs used. We will also perform a cost-effectiveness analysis based on results of the trial.DISCUSSION: The ANTLER trial findings will inform primary care prescribing practice by providing a valid and generalisable estimate of the clinical effectiveness and cost-effectiveness of long-term maintenance treatment with antidepressants in UK primary care.TRIAL REGISTRATION: Controlled Trials ISRCTN Registry, ISRCTN15969819. Registered on 21 September 2015.",
keywords = "Antidepressants, Citalopram, Depression, Fluoxetine, Mirtazapine, Primary care, Selective serotonin reuptake inhibitors, Sertraline",
author = "Larisa Duffy and Faye Bacon and Clarke, {Caroline S} and Yvonne Donkor and Nick Freemantle and Simon Gilbody and Rachael Hunter and Tony Kendrick and David Kessler and Michael King and Paul Lanham and Gemma Lewis and Dee Mangin and Louise Marston and Michael Moore and Irwin Nazareth and Nicola Wiles and Glyn Lewis",
note = "{\circledC} The Author(s). 2019",
year = "2019",
month = "6",
day = "3",
doi = "10.1186/s13063-019-3390-8",
language = "English",
volume = "20",
pages = "319",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER

T2 - Trials

AU - Duffy, Larisa

AU - Bacon, Faye

AU - Clarke, Caroline S

AU - Donkor, Yvonne

AU - Freemantle, Nick

AU - Gilbody, Simon

AU - Hunter, Rachael

AU - Kendrick, Tony

AU - Kessler, David

AU - King, Michael

AU - Lanham, Paul

AU - Lewis, Gemma

AU - Mangin, Dee

AU - Marston, Louise

AU - Moore, Michael

AU - Nazareth, Irwin

AU - Wiles, Nicola

AU - Lewis, Glyn

N1 - © The Author(s). 2019

PY - 2019/6/3

Y1 - 2019/6/3

N2 - BACKGROUND: Antidepressants are used both for treating acute episodes and for prophylaxis to prevent future episodes of depression, also called maintenance treatment. This article describes the protocol for a randomised controlled trial (ANTLER: ANTidepressants to prevent reLapse in dEpRession) to investigate the clinical effectiveness and cost-effectiveness in UK primary care of continuing on long-term maintenance antidepressants compared with a placebo in preventing relapse of depression in those who have taken antidepressants for more than 9 months and who are currently well enough to consider stopping maintenance treatment.METHODS/DESIGN: The ANTLER trial is an individually randomised, double-blind, placebo-controlled trial in which participants are randomised to remain on active medication or to take an identical placebo after a tapering period of 2 months. Eligible participants are those who: are between the ages of 18 and 74 years; have had at least two episodes of depression; and have been taking antidepressants for 9 months or more and are currently taking citalopram 20 mg, sertraline 100 mg, fluoxetine 20 mg or mirtazapine 30 mg but are well enough to consider stopping their medication. The participants will be followed up at 6, 12, 26, 39 and 52 weeks. The primary outcome will be the time in weeks to the beginning of the first episode of depression after randomisation. This will be measured using a retrospective version of the Clinical Interview Schedule-Revised administered at 12, 26, 39 and 52 weeks. Secondary outcomes will include depressive and anxiety symptoms, adverse effects, withdrawal symptoms, emotional processing tasks, quality of life and the resources and costs used. We will also perform a cost-effectiveness analysis based on results of the trial.DISCUSSION: The ANTLER trial findings will inform primary care prescribing practice by providing a valid and generalisable estimate of the clinical effectiveness and cost-effectiveness of long-term maintenance treatment with antidepressants in UK primary care.TRIAL REGISTRATION: Controlled Trials ISRCTN Registry, ISRCTN15969819. Registered on 21 September 2015.

AB - BACKGROUND: Antidepressants are used both for treating acute episodes and for prophylaxis to prevent future episodes of depression, also called maintenance treatment. This article describes the protocol for a randomised controlled trial (ANTLER: ANTidepressants to prevent reLapse in dEpRession) to investigate the clinical effectiveness and cost-effectiveness in UK primary care of continuing on long-term maintenance antidepressants compared with a placebo in preventing relapse of depression in those who have taken antidepressants for more than 9 months and who are currently well enough to consider stopping maintenance treatment.METHODS/DESIGN: The ANTLER trial is an individually randomised, double-blind, placebo-controlled trial in which participants are randomised to remain on active medication or to take an identical placebo after a tapering period of 2 months. Eligible participants are those who: are between the ages of 18 and 74 years; have had at least two episodes of depression; and have been taking antidepressants for 9 months or more and are currently taking citalopram 20 mg, sertraline 100 mg, fluoxetine 20 mg or mirtazapine 30 mg but are well enough to consider stopping their medication. The participants will be followed up at 6, 12, 26, 39 and 52 weeks. The primary outcome will be the time in weeks to the beginning of the first episode of depression after randomisation. This will be measured using a retrospective version of the Clinical Interview Schedule-Revised administered at 12, 26, 39 and 52 weeks. Secondary outcomes will include depressive and anxiety symptoms, adverse effects, withdrawal symptoms, emotional processing tasks, quality of life and the resources and costs used. We will also perform a cost-effectiveness analysis based on results of the trial.DISCUSSION: The ANTLER trial findings will inform primary care prescribing practice by providing a valid and generalisable estimate of the clinical effectiveness and cost-effectiveness of long-term maintenance treatment with antidepressants in UK primary care.TRIAL REGISTRATION: Controlled Trials ISRCTN Registry, ISRCTN15969819. Registered on 21 September 2015.

KW - Antidepressants

KW - Citalopram

KW - Depression

KW - Fluoxetine

KW - Mirtazapine

KW - Primary care

KW - Selective serotonin reuptake inhibitors

KW - Sertraline

UR - http://www.scopus.com/inward/record.url?scp=85066832281&partnerID=8YFLogxK

U2 - 10.1186/s13063-019-3390-8

DO - 10.1186/s13063-019-3390-8

M3 - Article

VL - 20

SP - 319

JO - Trials

JF - Trials

SN - 1745-6215

IS - 1

M1 - 319

ER -