A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products

Matthew G. Lloyd, Mariantonietta D'Acunto, Richard J K Taylor*, William P. Unsworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.

Original languageEnglish
Pages (from-to)1641-1645
Number of pages5
JournalOrganic and Biomolecular Chemistry
Issue number5
Early online date17 Dec 2015
Publication statusPublished - 7 Feb 2016

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