A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products

Matthew G. Lloyd, Mariantonietta D'Acunto, Richard J K Taylor*, William P. Unsworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.

Original languageEnglish
Pages (from-to)1641-1645
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number5
Early online date17 Dec 2015
DOIs
Publication statusPublished - 7 Feb 2016

Bibliographical note

© Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Cite this