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A selective C-H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products

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JournalOrganic and Biomolecular Chemistry
DateAccepted/In press - 17 Dec 2015
DateE-pub ahead of print - 17 Dec 2015
DatePublished (current) - 7 Feb 2016
Issue number5
Volume14
Number of pages5
Pages (from-to)1641-1645
Early online date17/12/15
Original languageEnglish

Abstract

A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.

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© Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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