A Simple and Cost-efficient Technique to Generate Hyperpolarized Long-lived 15N-15N Nuclear Spin Order in a Diazine by Signal Amplification by Reversible Exchange

TY - JOUR

T1 - A Simple and Cost-efficient Technique to Generate Hyperpolarized Long-lived 15N-15N Nuclear Spin Order in a Diazine by Signal Amplification by Reversible Exchange

AU - Roy, S. S.

AU - Rayner, Peter John

AU - Burns, Michael

AU - Duckett, Simon B.

N1 - © The Authors, 2020.

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique and is capable of boosting Nuclear Magnetic Resonance (NMR) sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen as hydride ligands and a substrate of interest to a metal catalyst to allow polarization transfer from para-hydrogen to the substrate nuclear spins. The nuclear spin lifetime of the created magnetization sets a strict upper limit on experimental timeframe. Short nuclear spin lifetimes are therefore a challenge for hyperpolarized metabolic imaging prospects. In this report we demonstrate how hyperpolarization and long nuclear spin lifetime can simultaneously be achieved in nitrogen-15 containing pyridazine and phthalazine derivatives by SABRE. These reflect two distinct classes of 15N2-coupled species with respect to their chemical symmetry and thus show different nuclear spin lifetime with the pyridazine derivative having a singlet state lifetime of ca. 2.5 minutes, produced with a signal enhancement of ca. 2,700. In contrast the phthalazine derivative yields a superior 15,000-fold enhancement at 11.7 T but has a much shorter singlet lifetime.

AB - Signal Amplification by Reversible Exchange (SABRE) is an inexpensive and simple hyperpolarization technique and is capable of boosting Nuclear Magnetic Resonance (NMR) sensitivity by several orders of magnitude. It utilizes the reversible binding of para-hydrogen as hydride ligands and a substrate of interest to a metal catalyst to allow polarization transfer from para-hydrogen to the substrate nuclear spins. The nuclear spin lifetime of the created magnetization sets a strict upper limit on experimental timeframe. Short nuclear spin lifetimes are therefore a challenge for hyperpolarized metabolic imaging prospects. In this report we demonstrate how hyperpolarization and long nuclear spin lifetime can simultaneously be achieved in nitrogen-15 containing pyridazine and phthalazine derivatives by SABRE. These reflect two distinct classes of 15N2-coupled species with respect to their chemical symmetry and thus show different nuclear spin lifetime with the pyridazine derivative having a singlet state lifetime of ca. 2.5 minutes, produced with a signal enhancement of ca. 2,700. In contrast the phthalazine derivative yields a superior 15,000-fold enhancement at 11.7 T but has a much shorter singlet lifetime.

U2 - 10.1063/1.5132308

DO - 10.1063/1.5132308

M3 - Article

SN - 0021-9606

VL - 152

JO - The Journal of Chemical Physics

JF - The Journal of Chemical Physics

M1 - 014201

ER -