Abstract
A new and efficient approach to chaetomellic anhydride A has been devised starting from 2,2-dichloropalmitic acid. This involves the atom transfer radical cyclization of an N-alkyl-N-(3-chloro-2-propenyl)amide followed by rearrangement of the resulting trichloro-pyrrolidin-2-one.
Original language | English |
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Pages (from-to) | 1680-1686 |
Number of pages | 7 |
Journal | SYNTHESIS-STUTTGART |
Issue number | 10 |
DOIs | |
Publication status | Published - 5 Jul 2004 |
Keywords
- amides
- cyclisations
- halogenation
- pyrrolidinones
- radical reactions
- TRANSFER RADICAL CYCLIZATION
- FACILE SYNTHESIS
- ACID-A
- FARNESYLTRANSFERASE INHIBITORS
- CUCL-TMEDA
- ANALOGS
- REARRANGEMENT
- N-ALLYL-N-BENZYL-2,2-DIHALOAMIDES
- CHLORINATION