By the same authors

From the same journal

A simple and efficient route to chaetomellic anhydride A: A potent natural Ras farnesyl-protein transferase inhibitor

Research output: Contribution to journalArticle

Published copy (DOI)

Author(s)

  • L De Buyck
  • R Cagnoli
  • F Ghelfi
  • G Merighi
  • A Mucci
  • U M Pagnoni
  • A F Parsons

Department/unit(s)

Publication details

JournalSYNTHESIS-STUTTGART
DatePublished - 5 Jul 2004
Issue number10
Number of pages7
Pages (from-to)1680-1686
Original languageEnglish

Abstract

A new and efficient approach to chaetomellic anhydride A has been devised starting from 2,2-dichloropalmitic acid. This involves the atom transfer radical cyclization of an N-alkyl-N-(3-chloro-2-propenyl)amide followed by rearrangement of the resulting trichloro-pyrrolidin-2-one.

    Research areas

  • amides, cyclisations, halogenation, pyrrolidinones, radical reactions, TRANSFER RADICAL CYCLIZATION, FACILE SYNTHESIS, ACID-A, FARNESYLTRANSFERASE INHIBITORS, CUCL-TMEDA, ANALOGS, REARRANGEMENT, N-ALLYL-N-BENZYL-2,2-DIHALOAMIDES, CHLORINATION

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