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A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers

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JournalChemical communications
DatePublished - 25 May 2013
Issue number42
Volume49
Pages (from-to)4830-4832
Original languageEnglish

Abstract

We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum-using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.

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