A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

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Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.

Original languageEnglish
Pages (from-to)10496-10500
Number of pages5
JournalChemistry : A European Journal
Issue number44
Early online date19 Jun 2017
Publication statusPublished - 19 Jul 2017

Bibliographical note

© 2017 Wiley-VCH


  • Hyperpolarization
  • Long-lived singlet states
  • NMR spectroscopy
  • para-hydrogen
  • Structure elucidation

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