A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

Soumya S. Roy; Philip Norcott; Peter J. Rayner; Gary G.R. Green; Simon B. Duckett

doi:10.1002/chem.201702767

A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

Soumya S. Roy, Philip Norcott, Peter J. Rayner, Gary G.R. Green, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in ¹³C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a ¹³C-signal that is visible for 10 minutes.

Original language	English
Pages (from-to)	10496-10500
Number of pages	5
Journal	Chemistry : A European Journal
Volume	23
Issue number	44
Early online date	19 Jun 2017
DOIs	https://doi.org/10.1002/chem.201702767 https://doi.org/10.1002/chem.201702767
Publication status	Published - 19 Jul 2017

Bibliographical note

Keywords

Hyperpolarization
Long-lived singlet states
NMR spectroscopy
para-hydrogen
Structure elucidation

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Accepted Article
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
Accepted author manuscript, 564 KBLicence: Other
A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes
© 2017 Wiley-VCH
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Cite this

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title = "A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes",

abstract = "Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.",

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AU - Roy, Soumya S.

AU - Norcott, Philip

AU - Rayner, Peter J.

AU - Green, Gary G.R.

AU - Duckett, Simon B.

PY - 2017/7/19

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N2 - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.

AB - Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.

KW - Hyperpolarization

KW - Long-lived singlet states

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A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Hyperpolarisation using SABRE as a new tool for imaging

Illustration of a simple route to generate strong carbon-13 NMR signals that are detectable for several minutes

Cite this

A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Projects

Hyperpolarisation using SABRE as a new tool for imaging

Datasets

Illustration of a simple route to generate strong carbon-13 NMR signals that are detectable for several minutes

Cite this