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From the same journal

A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

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Publication details

JournalChemistry : A European Journal
DateAccepted/In press - 16 Jun 2017
DateE-pub ahead of print - 19 Jun 2017
DatePublished (current) - 19 Jul 2017
Number of pages6
Early online date19/06/17
Original languageEnglish

Abstract

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low-field storage with para-hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p-tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190s in low-field, which leads to a 13C-signal that is visible for 10 minutes.

Bibliographical note

© 2017 Wiley-VCH

    Research areas

  • Hyperpolarization, Long-lived singlet states, NMR spectroscopy, para-hydrogen, Structure elucidation

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