TY - JOUR
T1 - A stromal cell niche for human and mouse type 3 innate lymphoid cells
AU - Hoorweg, Kerim
AU - Narang, Priyanka
AU - Li, Zhi
AU - Thuery, Anne
AU - Papazian, Natalie
AU - Withers, David R.
AU - Coles, Mark C.
AU - Cupedo, Tom
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.
AB - Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs.
UR - http://www.scopus.com/inward/record.url?scp=84945121919&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1402584
DO - 10.4049/jimmunol.1402584
M3 - Article
AN - SCOPUS:84945121919
VL - 195
SP - 4257
EP - 4263
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -