A study into the use of microwaves and solid acid catalysts for Friedel-Crafts acetylations

M J  Gronnow; D J  Macquarrie; J H  Clark; P  Ravenscroft

doi:10.1016/j.molcata.2004.12.030

A study into the use of microwaves and solid acid catalysts for Friedel-Crafts acetylations

M J Gronnow, D J Macquarrie, J H Clark, P Ravenscroft

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A range of solid acids has been used for the acetylation of methyl salicylate by acetyl chloride/acetic anhydride. A comparison between microwave and traditional heating has been also been made. By comparing alummium chloride, sulfated zirconia, copper triflate on silica, heteropoly tungstic acid on silica and iron(III) chloride on clay (clayfec) a wide ranging comparison has been made and it has been discovered that solid acids can offer truly catalytic acetylations of relatively complex substrates albeit in lower yields than their traditional alternatives such as aluminium chloride. Microwave heating enables lower by-product formation and more importantly reaction times in the order of minutes as opposed to hours required by conventional means. (c) 2004 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	47-51
Number of pages	5
Journal	Journal of Molecular Catalysis A: Chemical
Volume	231
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molcata.2004.12.030
Publication status	Published - 20 Apr 2005

Keywords

microwaves
solid acid catalysts
Friedel-Crafts chemistry
acetylation
REARRANGEMENT
ACYLATION

Access to Document

10.1016/j.molcata.2004.12.030

Cite this

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title = "A study into the use of microwaves and solid acid catalysts for Friedel-Crafts acetylations",

abstract = "A range of solid acids has been used for the acetylation of methyl salicylate by acetyl chloride/acetic anhydride. A comparison between microwave and traditional heating has been also been made. By comparing alummium chloride, sulfated zirconia, copper triflate on silica, heteropoly tungstic acid on silica and iron(III) chloride on clay (clayfec) a wide ranging comparison has been made and it has been discovered that solid acids can offer truly catalytic acetylations of relatively complex substrates albeit in lower yields than their traditional alternatives such as aluminium chloride. Microwave heating enables lower by-product formation and more importantly reaction times in the order of minutes as opposed to hours required by conventional means. (c) 2004 Elsevier B.V. All rights reserved.",

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T1 - A study into the use of microwaves and solid acid catalysts for Friedel-Crafts acetylations

AU - Gronnow, M J

AU - Macquarrie, D J

AU - Clark, J H

AU - Ravenscroft, P

PY - 2005/4/20

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N2 - A range of solid acids has been used for the acetylation of methyl salicylate by acetyl chloride/acetic anhydride. A comparison between microwave and traditional heating has been also been made. By comparing alummium chloride, sulfated zirconia, copper triflate on silica, heteropoly tungstic acid on silica and iron(III) chloride on clay (clayfec) a wide ranging comparison has been made and it has been discovered that solid acids can offer truly catalytic acetylations of relatively complex substrates albeit in lower yields than their traditional alternatives such as aluminium chloride. Microwave heating enables lower by-product formation and more importantly reaction times in the order of minutes as opposed to hours required by conventional means. (c) 2004 Elsevier B.V. All rights reserved.

AB - A range of solid acids has been used for the acetylation of methyl salicylate by acetyl chloride/acetic anhydride. A comparison between microwave and traditional heating has been also been made. By comparing alummium chloride, sulfated zirconia, copper triflate on silica, heteropoly tungstic acid on silica and iron(III) chloride on clay (clayfec) a wide ranging comparison has been made and it has been discovered that solid acids can offer truly catalytic acetylations of relatively complex substrates albeit in lower yields than their traditional alternatives such as aluminium chloride. Microwave heating enables lower by-product formation and more importantly reaction times in the order of minutes as opposed to hours required by conventional means. (c) 2004 Elsevier B.V. All rights reserved.

KW - microwaves

KW - solid acid catalysts

KW - Friedel-Crafts chemistry

KW - acetylation

KW - REARRANGEMENT

KW - ACYLATION

U2 - 10.1016/j.molcata.2004.12.030

DO - 10.1016/j.molcata.2004.12.030

M3 - Article

SN - 1381-1169

VL - 231

SP - 47

EP - 51

JO - Journal of Molecular Catalysis A: Chemical

JF - Journal of Molecular Catalysis A: Chemical

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