A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones

James D. Cuthbertson; Andrew A. Godfrey; Richard J. K. Taylor

doi:10.1055/s-0030-1258811

A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones

James D. Cuthbertson, Andrew A. Godfrey, Richard J. K. Taylor

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.

Original language	English
Pages (from-to)	2805-2807
Number of pages	3
Journal	Synlett
Issue number	18
DOIs	https://doi.org/10.1055/s-0030-1258811
Publication status	Published - Nov 2010

Keywords

amination
lactamisation
azabicyclo[2.2.2]octanones
bicyclic compounds
6-carboalkoxycyclohex-2-enones

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10.1055/s-0030-1258811

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abstract = "An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.",

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AU - Taylor, Richard J. K.

PY - 2010/11

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AB - An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.

KW - amination

KW - lactamisation

KW - azabicyclo[2.2.2]octanones

KW - bicyclic compounds

KW - 6-carboalkoxycyclohex-2-enones

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ER -

A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones

Abstract

Keywords

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