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A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones

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JournalSynlett
DatePublished - Nov 2010
Issue number18
Number of pages3
Pages (from-to)2805-2807
Original languageEnglish

Abstract

An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.

    Research areas

  • amination, lactamisation, azabicyclo[2.2.2]octanones, bicyclic compounds, 6-carboalkoxycyclohex-2-enones

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