Research output: Contribution to journal › Article › peer-review
A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones. / Cuthbertson, James D.; Godfrey, Andrew A.; Taylor, Richard J. K.
In: Synlett, No. 18, 11.2010, p. 2805-2807.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - A Tandem Amination/Lactamisation Route to 2-Azabicyclo[2.2.2]octanones
AU - Cuthbertson, James D.
AU - Godfrey, Andrew A.
AU - Taylor, Richard J. K.
PY - 2010/11
Y1 - 2010/11
N2 - An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.
AB - An efficient one-pot amination/lactamisation sequence for the preparation of 2-azabicyclo[2.2.2]octanones from 6-carboalkoxycyclohex-2-enones and aqueous ammonia is described. Scope and limitation studies are reported for this tandem procedure and a range of bicyclic compounds have been prepared, two of which were characterised by X-ray crystallography.
KW - amination
KW - lactamisation
KW - azabicyclo[2.2.2]octanones
KW - bicyclic compounds
KW - 6-carboalkoxycyclohex-2-enones
UR - http://www.scopus.com/inward/record.url?scp=78149285464&partnerID=8YFLogxK
U2 - 10.1055/s-0030-1258811
DO - 10.1055/s-0030-1258811
M3 - Article
SP - 2805
EP - 2807
JO - Synlett
JF - Synlett
SN - 1437-2096
IS - 18
ER -