Abstract
An operationally simple, high yielding three-step cascade process is described for the direct conversion of indole-tethered ynones into functionalized quinolines. A single "multitasking" thiol reagent is used to promote a three-step dearomatizing spirocyclization, nucleophilic substitution, and one-atom ring expansion reaction cascade under remarkably mild conditions. In addition, a novel route to thio-oxindoles is described, which was discovered by serendipity.
Original language | English |
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Pages (from-to) | 2063-2068 |
Journal | Organic letters |
Volume | 23 |
Issue number | 6 |
Early online date | 1 Mar 2021 |
DOIs | |
Publication status | E-pub ahead of print - 1 Mar 2021 |