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A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer

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JournalChemical Communications
DatePublished - 2003
Issue number8
Number of pages2
Pages (from-to)944-945
Original languageEnglish

Abstract

The atomic-resolution structure of a xylobiose-derived isofagomine lactam in complex with the xylanase Xyn10A from Streptomyces lividans reveals that the lactam is bound to the enzyme as the amide tautomer, with "reversed" protonation-states for nucleophile and acid-base.

    Research areas

  • KINETIC-ANALYSIS

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