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Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study

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JournalCHEMMEDCHEM
DateAccepted/In press - 12 Dec 2017
DateE-pub ahead of print (current) - 12 Dec 2017
Number of pages9
Early online date12/12/17
Original languageEnglish

Abstract

Production of a biocompatible hyperpolarized bolus for signal amplification by reversible exchange (SABRE) could open the door to simple clinical diagnosis via magnetic resonance imaging. Essential to successful progression to preclinical/clinical applications is the determination of the toxicology profile of the SABRE reaction mixture. Herein, we exemplify the cytotoxicity of the SABRE approach using invitro cell assays. We conclude that the main cause of the observed toxicity is due to the SABRE catalyst. We therefore illustrate two catalyst removal methods: one involving deactivation and ion-exchange chromatography, and the second using biphasic catalysis. These routes produce a bolus suitable for future invivo study.

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© 2018, The Authors.

    Research areas

  • Biocompatibility, Biphasic catalysis, Cytotoxicity, Hyperpolarization, SABRE

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