Achieving Controlled Biomolecule-Biomaterial Conjugation

Christopher D. Spicer*, E. Thomas Pashuck, Molly M. Stevens

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.

Original languageEnglish
Pages (from-to)7702-7743
Number of pages42
JournalChemical Reviews
Issue number16
Publication statusPublished - 22 Aug 2018

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© 2018, The Author(s).

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