Achieving Controlled Biomolecule-Biomaterial Conjugation

Christopher D. Spicer; E. Thomas Pashuck; Molly M. Stevens

doi:10.1021/acs.chemrev.8b00253

Achieving Controlled Biomolecule-Biomaterial Conjugation

Christopher D. Spicer^*, E. Thomas Pashuck, Molly M. Stevens

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.

Original language	English
Pages (from-to)	7702-7743
Number of pages	42
Journal	Chemical Reviews
Volume	118
Issue number	16
DOIs	https://doi.org/10.1021/acs.chemrev.8b00253
Publication status	Published - 22 Aug 2018

Bibliographical note

Access to Document

10.1021/acs.chemrev.8b00253Licence: CC BY

acs.chemrev.8b00253
© 2018, The Author(s).
Final published version, 8.81 MBLicence: CC BY

Cite this

@article{dd32a3e9672847108189c5250f473517,

title = "Achieving Controlled Biomolecule-Biomaterial Conjugation",

abstract = "The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.",

author = "Spicer, {Christopher D.} and Pashuck, {E. Thomas} and Stevens, {Molly M.}",

note = "{\textcopyright} 2018, The Author(s). ",

year = "2018",

month = aug,

day = "22",

doi = "10.1021/acs.chemrev.8b00253",

language = "English",

volume = "118",

pages = "7702--7743",

journal = "Chemical Reviews",

issn = "0009-2665",

publisher = "American Chemical Society",

number = "16",

}

TY - JOUR

T1 - Achieving Controlled Biomolecule-Biomaterial Conjugation

AU - Spicer, Christopher D.

AU - Pashuck, E. Thomas

AU - Stevens, Molly M.

PY - 2018/8/22

Y1 - 2018/8/22

N2 - The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.

AB - The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.

UR - http://www.scopus.com/inward/record.url?scp=85052062981&partnerID=8YFLogxK

U2 - 10.1021/acs.chemrev.8b00253

DO - 10.1021/acs.chemrev.8b00253

M3 - Review article

AN - SCOPUS:85052062981

SN - 0009-2665

VL - 118

SP - 7702

EP - 7743

JO - Chemical Reviews

JF - Chemical Reviews

IS - 16

ER -

Achieving Controlled Biomolecule-Biomaterial Conjugation

Abstract

Bibliographical note

Access to Document

Other files and links

Cite this