Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination via SABRE

TY - JOUR

T1 - Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination via SABRE

AU - Iali, Wissam

AU - Olaru, Alexandra M.

AU - Green, Gary G.R.

AU - Duckett, Simon B.

N1 - © 2017, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

PY - 2017/7/19

Y1 - 2017/7/19

N2 - Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced 1H NMR signals in a range of substrates in aqueous media. In order to achieve this outcome phase-transfer-catalysis is exploited which leads to less than less than 1.5 x 10-6 mol dm-3 of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. The new process has been called CAtalyst Separated Hyperpolarization via Signal Amplification By Reversible Exchange or CASH-SABRE. We illustrate this method for the substrates pyrazine, 5-methylpyrimidine, 4,6-d2-methyl nicotinate, 4,6-d2-nicotinamide and pyridazine achieving 1H signals gains of approximately 790-, 340-, 3000-, 260- and 380-fold per proton at 9.4 T at the time point where phase separation is complete.

AB - Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced 1H NMR signals in a range of substrates in aqueous media. In order to achieve this outcome phase-transfer-catalysis is exploited which leads to less than less than 1.5 x 10-6 mol dm-3 of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. The new process has been called CAtalyst Separated Hyperpolarization via Signal Amplification By Reversible Exchange or CASH-SABRE. We illustrate this method for the substrates pyrazine, 5-methylpyrimidine, 4,6-d2-methyl nicotinate, 4,6-d2-nicotinamide and pyridazine achieving 1H signals gains of approximately 790-, 340-, 3000-, 260- and 380-fold per proton at 9.4 T at the time point where phase separation is complete.

KW - Hyperpolarization

KW - NMR spectroscopy

KW - para-hydrogen

KW - SABRE

UR - http://www.scopus.com/inward/record.url?scp=85025070782&partnerID=8YFLogxK

U2 - 10.1002/chem.201702716

DO - 10.1002/chem.201702716

M3 - Article

AN - SCOPUS:85025070782

SN - 0947-6539

VL - 23

SP - 10491

EP - 10495

JO - Chemistry : A European Journal

JF - Chemistry : A European Journal

IS - 44

M1 - EMID:5887bf1d5bf20112

ER -