Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination via SABRE

Wissam Iali, Alexandra M. Olaru, Gary G.R. Green, Simon B. Duckett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Signal amplification by reversible exchange (SABRE) is shown to allow access to strongly enhanced 1H NMR signals in a range of substrates in aqueous media. In order to achieve this outcome phase-transfer-catalysis is exploited which leads to less than less than 1.5 x 10-6 mol dm-3 of the iridium catalyst in the aqueous phase. These observations reflect a compelling route to produce a saline based hyperpolarized bolus in just a few seconds for subsequent in vivo MRI monitoring. The new process has been called CAtalyst Separated Hyperpolarization via Signal Amplification By Reversible Exchange or CASH-SABRE. We illustrate this method for the substrates pyrazine, 5-methylpyrimidine, 4,6-d2-methyl nicotinate, 4,6-d2-nicotinamide and pyridazine achieving 1H signals gains of approximately 790-, 340-, 3000-, 260- and 380-fold per proton at 9.4 T at the time point where phase separation is complete.
Original languageEnglish
Article numberEMID:5887bf1d5bf20112
Pages (from-to)10491–10495
Number of pages6
JournalChemistry : A European Journal
Issue number44
Early online date13 Jun 2017
Publication statusPublished - 19 Jul 2017

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© 2017, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.


  • Hyperpolarization
  • NMR spectroscopy
  • para-hydrogen

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