Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function

P M Kaye; N K Patel; J M Blackwell

Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function

P M Kaye, N K Patel, J M Blackwell

The Hull York Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

The macrophage natural resistance gene. Lsh, regulates the ability of a selective population of tissue macrophages to control intracellular multiplication of Leishmania donovani by a T-cell independent mechanism. We show here, using mice congenic for Lsh, that this gene also contributes to the acquisition of T-cell-mediated immunity. Whereas both resistant and susceptible mice generate equivalent primary T-cell responses to infection, resistant mice show a rapid increase in accessory cell activity, allowing for greater subsequent T-cell expansion. This change in accessory cell function correlates with increased class II antigen expression relative to susceptible mice, both in vivo during early infection and in vitro in response to induction by interferon-gamma (IFN-gamma). Differences in vitro were independent of, but differentially affected by, amastigote infection.

Original language	English
Pages (from-to)	17-22
Number of pages	6
Journal	Immunology
Volume	65
Issue number	1
Publication status	Published - Sept 1988

Keywords

Animals
Antigen-Presenting Cells
Genes, MHC Class II
Histocompatibility Antigens Class II
Immunity, Cellular
Immunologic Memory
Leishmaniasis, Visceral
Mice
Mice, Inbred Strains
T-Lymphocytes

Cite this

@article{2af88533e9cd47aaae6affd8d30f3370,

title = "Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function",

abstract = "The macrophage natural resistance gene. Lsh, regulates the ability of a selective population of tissue macrophages to control intracellular multiplication of Leishmania donovani by a T-cell independent mechanism. We show here, using mice congenic for Lsh, that this gene also contributes to the acquisition of T-cell-mediated immunity. Whereas both resistant and susceptible mice generate equivalent primary T-cell responses to infection, resistant mice show a rapid increase in accessory cell activity, allowing for greater subsequent T-cell expansion. This change in accessory cell function correlates with increased class II antigen expression relative to susceptible mice, both in vivo during early infection and in vitro in response to induction by interferon-gamma (IFN-gamma). Differences in vitro were independent of, but differentially affected by, amastigote infection.",

keywords = "Animals, Antigen-Presenting Cells, Genes, MHC Class II, Histocompatibility Antigens Class II, Immunity, Cellular, Immunologic Memory, Leishmaniasis, Visceral, Mice, Mice, Inbred Strains, T-Lymphocytes",

author = "Kaye, {P M} and Patel, {N K} and Blackwell, {J M}",

year = "1988",

month = sep,

language = "English",

volume = "65",

pages = "17--22",

journal = "Immunology",

issn = "0019-2805",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Acquisition of cell-mediated immunity to Leishmania. II. LSH gene regulation of accessory cell function

AU - Kaye, P M

AU - Patel, N K

AU - Blackwell, J M

PY - 1988/9

Y1 - 1988/9

N2 - The macrophage natural resistance gene. Lsh, regulates the ability of a selective population of tissue macrophages to control intracellular multiplication of Leishmania donovani by a T-cell independent mechanism. We show here, using mice congenic for Lsh, that this gene also contributes to the acquisition of T-cell-mediated immunity. Whereas both resistant and susceptible mice generate equivalent primary T-cell responses to infection, resistant mice show a rapid increase in accessory cell activity, allowing for greater subsequent T-cell expansion. This change in accessory cell function correlates with increased class II antigen expression relative to susceptible mice, both in vivo during early infection and in vitro in response to induction by interferon-gamma (IFN-gamma). Differences in vitro were independent of, but differentially affected by, amastigote infection.

AB - The macrophage natural resistance gene. Lsh, regulates the ability of a selective population of tissue macrophages to control intracellular multiplication of Leishmania donovani by a T-cell independent mechanism. We show here, using mice congenic for Lsh, that this gene also contributes to the acquisition of T-cell-mediated immunity. Whereas both resistant and susceptible mice generate equivalent primary T-cell responses to infection, resistant mice show a rapid increase in accessory cell activity, allowing for greater subsequent T-cell expansion. This change in accessory cell function correlates with increased class II antigen expression relative to susceptible mice, both in vivo during early infection and in vitro in response to induction by interferon-gamma (IFN-gamma). Differences in vitro were independent of, but differentially affected by, amastigote infection.

KW - Animals

KW - Antigen-Presenting Cells

KW - Genes, MHC Class II

KW - Histocompatibility Antigens Class II

KW - Immunity, Cellular

KW - Immunologic Memory

KW - Leishmaniasis, Visceral

KW - Mice

KW - Mice, Inbred Strains

KW - T-Lymphocytes

M3 - Article

C2 - 3141269

SN - 0019-2805

VL - 65

SP - 17

EP - 22

JO - Immunology

JF - Immunology

IS - 1

ER -