By the same authors

Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology

Research output: Chapter in Book/Report/Conference proceedingChapter

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Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology. / De Bruin, Gerjan; Li, Nan; Paniagua, Guillem; Willems, Lianne; Xin, Bo Tao; Verdoes, Martijn; Geurink, Paul P.; Van Der Linden, Wouter; van der Stelt, Mario; Van Der Marel, Gijs; Overkleeft, Herman S.; Florea, Bogdan I.

Concepts and Case Studies in Chemical Biology. Wiley, 2014. p. 177-190.

Research output: Chapter in Book/Report/Conference proceedingChapter

Harvard

De Bruin, G, Li, N, Paniagua, G, Willems, L, Xin, BT, Verdoes, M, Geurink, PP, Van Der Linden, W, van der Stelt, M, Van Der Marel, G, Overkleeft, HS & Florea, BI 2014, Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology. in Concepts and Case Studies in Chemical Biology. Wiley, pp. 177-190. https://doi.org/10.1002/9783527687503.ch12

APA

De Bruin, G., Li, N., Paniagua, G., Willems, L., Xin, B. T., Verdoes, M., Geurink, P. P., Van Der Linden, W., van der Stelt, M., Van Der Marel, G., Overkleeft, H. S., & Florea, B. I. (2014). Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology. In Concepts and Case Studies in Chemical Biology (pp. 177-190). Wiley. https://doi.org/10.1002/9783527687503.ch12

Vancouver

De Bruin G, Li N, Paniagua G, Willems L, Xin BT, Verdoes M et al. Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology. In Concepts and Case Studies in Chemical Biology. Wiley. 2014. p. 177-190 https://doi.org/10.1002/9783527687503.ch12

Author

De Bruin, Gerjan ; Li, Nan ; Paniagua, Guillem ; Willems, Lianne ; Xin, Bo Tao ; Verdoes, Martijn ; Geurink, Paul P. ; Van Der Linden, Wouter ; van der Stelt, Mario ; Van Der Marel, Gijs ; Overkleeft, Herman S. ; Florea, Bogdan I. / Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology. Concepts and Case Studies in Chemical Biology. Wiley, 2014. pp. 177-190

Bibtex - Download

@inbook{b7958a1beeaa426e9ec33215a527719f,
title = "Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology",
abstract = "Activity-based protein profiling (ABPP) is a powerful technique to identify enzymatic activities and to study their functioning - and the effect of inhibitors on this - in vitro, in situ, and in vivo. In this chapter some case studies on activity-based profiling of mammalian proteasomes are discussed. Both direct and two-step bioorthogonal ABPP strategies and their merits are discussed, and the value of ABPP in the establishment of previously uncharted enzymatic activities and the direct visualization of inhibitor specificity are presented. Proteasomes are essential factors in the detection and eradication of virally infected cells. Besides their fundamental interest, proteasomes are relevant therapeutic targets. Proteasomes are useful targets in the development of chemical biology research strategies, and in return chemical biology approaches help in establishing proteasome activities in health and disease and in determining their relevance as drug targets.",
keywords = "Activity-based proteasome profiling (ABPP), Chemical biology, Medicinal chemistry",
author = "{De Bruin}, Gerjan and Nan Li and Guillem Paniagua and Lianne Willems and Xin, {Bo Tao} and Martijn Verdoes and Geurink, {Paul P.} and {Van Der Linden}, Wouter and {van der Stelt}, Mario and {Van Der Marel}, Gijs and Overkleeft, {Herman S.} and Florea, {Bogdan I.}",
year = "2014",
month = oct,
day = "6",
doi = "10.1002/9783527687503.ch12",
language = "English",
isbn = "9783527336111",
pages = "177--190",
booktitle = "Concepts and Case Studies in Chemical Biology",
publisher = "Wiley",
address = "United States",

}

RIS (suitable for import to EndNote) - Download

TY - CHAP

T1 - Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology

AU - De Bruin, Gerjan

AU - Li, Nan

AU - Paniagua, Guillem

AU - Willems, Lianne

AU - Xin, Bo Tao

AU - Verdoes, Martijn

AU - Geurink, Paul P.

AU - Van Der Linden, Wouter

AU - van der Stelt, Mario

AU - Van Der Marel, Gijs

AU - Overkleeft, Herman S.

AU - Florea, Bogdan I.

PY - 2014/10/6

Y1 - 2014/10/6

N2 - Activity-based protein profiling (ABPP) is a powerful technique to identify enzymatic activities and to study their functioning - and the effect of inhibitors on this - in vitro, in situ, and in vivo. In this chapter some case studies on activity-based profiling of mammalian proteasomes are discussed. Both direct and two-step bioorthogonal ABPP strategies and their merits are discussed, and the value of ABPP in the establishment of previously uncharted enzymatic activities and the direct visualization of inhibitor specificity are presented. Proteasomes are essential factors in the detection and eradication of virally infected cells. Besides their fundamental interest, proteasomes are relevant therapeutic targets. Proteasomes are useful targets in the development of chemical biology research strategies, and in return chemical biology approaches help in establishing proteasome activities in health and disease and in determining their relevance as drug targets.

AB - Activity-based protein profiling (ABPP) is a powerful technique to identify enzymatic activities and to study their functioning - and the effect of inhibitors on this - in vitro, in situ, and in vivo. In this chapter some case studies on activity-based profiling of mammalian proteasomes are discussed. Both direct and two-step bioorthogonal ABPP strategies and their merits are discussed, and the value of ABPP in the establishment of previously uncharted enzymatic activities and the direct visualization of inhibitor specificity are presented. Proteasomes are essential factors in the detection and eradication of virally infected cells. Besides their fundamental interest, proteasomes are relevant therapeutic targets. Proteasomes are useful targets in the development of chemical biology research strategies, and in return chemical biology approaches help in establishing proteasome activities in health and disease and in determining their relevance as drug targets.

KW - Activity-based proteasome profiling (ABPP)

KW - Chemical biology

KW - Medicinal chemistry

UR - http://www.scopus.com/inward/record.url?scp=84926402700&partnerID=8YFLogxK

U2 - 10.1002/9783527687503.ch12

DO - 10.1002/9783527687503.ch12

M3 - Chapter

AN - SCOPUS:84926402700

SN - 9783527336111

SP - 177

EP - 190

BT - Concepts and Case Studies in Chemical Biology

PB - Wiley

ER -