Acyl-CoA measurements in plants suggest a role in regulating various cellular processes

I A Graham; Y Li; T R Larson

Acyl-CoA measurements in plants suggest a role in regulating various cellular processes

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Abstract

Acyl-CoA esters have been shown to be involved in regulating metabolism and cell signalling in bacteria, yeast and mammalian cells, but little is known about their role in plants. Using a new method for the sensitive detection and quantification of acyl-CoA esters, we have recently shown that acyl-CoA pools can be dramatically altered in transgenic oilseed rape embryos, engineered to produce medium-chain fatty acids, and in mutant Arabidopsis seedlings that are unable to mobilize storage lipid. The consequences of these alterations are discussed in the context of oil yield and organelle biogenesis and the possible role of acyl-CoAs in regulating these processes.

Original language	English
Pages (from-to)	1095-1099
Number of pages	5
Journal	Biochemical Society transactions
Volume	30
Publication status	Published - Nov 2002

Keywords

Arabidopsis
oilseed
beta-oxidation
peroxisome
ACID BETA-OXIDATION
BINDING PROTEIN
LIPID BODIES
COENZYME-A
ARABIDOPSIS
METABOLISM
GLYOXYSOMES
INHIBITION
MECHANISM
ESTERS

Cite this

@article{36f29ad2e129449d892a3c46cd311da2,

title = "Acyl-CoA measurements in plants suggest a role in regulating various cellular processes",

abstract = "Acyl-CoA esters have been shown to be involved in regulating metabolism and cell signalling in bacteria, yeast and mammalian cells, but little is known about their role in plants. Using a new method for the sensitive detection and quantification of acyl-CoA esters, we have recently shown that acyl-CoA pools can be dramatically altered in transgenic oilseed rape embryos, engineered to produce medium-chain fatty acids, and in mutant Arabidopsis seedlings that are unable to mobilize storage lipid. The consequences of these alterations are discussed in the context of oil yield and organelle biogenesis and the possible role of acyl-CoAs in regulating these processes.",

keywords = "Arabidopsis, oilseed, beta-oxidation, peroxisome, ACID BETA-OXIDATION, BINDING PROTEIN, LIPID BODIES, COENZYME-A, ARABIDOPSIS, METABOLISM, GLYOXYSOMES, INHIBITION, MECHANISM, ESTERS",

author = "Graham, {I A} and Y Li and Larson, {T R}",

year = "2002",

month = nov,

language = "English",

volume = "30",

pages = "1095--1099",

journal = "Biochemical Society transactions",

issn = "1470-8752",

publisher = "Portland Press Ltd.",

}

TY - JOUR

T1 - Acyl-CoA measurements in plants suggest a role in regulating various cellular processes

AU - Graham, I A

AU - Li, Y

AU - Larson, T R

PY - 2002/11

Y1 - 2002/11

N2 - Acyl-CoA esters have been shown to be involved in regulating metabolism and cell signalling in bacteria, yeast and mammalian cells, but little is known about their role in plants. Using a new method for the sensitive detection and quantification of acyl-CoA esters, we have recently shown that acyl-CoA pools can be dramatically altered in transgenic oilseed rape embryos, engineered to produce medium-chain fatty acids, and in mutant Arabidopsis seedlings that are unable to mobilize storage lipid. The consequences of these alterations are discussed in the context of oil yield and organelle biogenesis and the possible role of acyl-CoAs in regulating these processes.

AB - Acyl-CoA esters have been shown to be involved in regulating metabolism and cell signalling in bacteria, yeast and mammalian cells, but little is known about their role in plants. Using a new method for the sensitive detection and quantification of acyl-CoA esters, we have recently shown that acyl-CoA pools can be dramatically altered in transgenic oilseed rape embryos, engineered to produce medium-chain fatty acids, and in mutant Arabidopsis seedlings that are unable to mobilize storage lipid. The consequences of these alterations are discussed in the context of oil yield and organelle biogenesis and the possible role of acyl-CoAs in regulating these processes.

KW - Arabidopsis

KW - oilseed

KW - beta-oxidation

KW - peroxisome

KW - ACID BETA-OXIDATION

KW - BINDING PROTEIN

KW - LIPID BODIES

KW - COENZYME-A

KW - ARABIDOPSIS

KW - METABOLISM

KW - GLYOXYSOMES

KW - INHIBITION

KW - MECHANISM

KW - ESTERS

M3 - Article

SN - 1470-8752

VL - 30

SP - 1095

EP - 1099

JO - Biochemical Society transactions

JF - Biochemical Society transactions

ER -