Abstract
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
Original language | English |
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Pages (from-to) | 773-776 |
Number of pages | 4 |
Journal | Infection and Immunity |
Volume | 74 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2006 |
Keywords
- DONOVANI INFECTION
- IFN-GAMMA
- LYMPHOCYTES
- ACTIVATION
- AMASTIGOTES
- SECRETION
- EXPANSION
- RESPONSES
- EFFECTOR
- IMMUNITY