Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen

R Polley, S Stager, S Prickett, A Maroof, S Zubairi, D F Smith, P M Kaye

Research output: Contribution to journalArticlepeer-review

Abstract

CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.

Original languageEnglish
Pages (from-to)773-776
Number of pages4
JournalInfection and Immunity
Volume74
Issue number1
DOIs
Publication statusPublished - Jan 2006

Keywords

  • DONOVANI INFECTION
  • IFN-GAMMA
  • LYMPHOCYTES
  • ACTIVATION
  • AMASTIGOTES
  • SECRETION
  • EXPANSION
  • RESPONSES
  • EFFECTOR
  • IMMUNITY

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