Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen

R Polley; S Stager; S Prickett; A Maroof; S Zubairi; D F Smith; P M Kaye

doi:10.1128/IAI.74.1.773-776.2006

Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen

R Polley, S Stager, S Prickett, A Maroof, S Zubairi, D F Smith, P M Kaye

Research output: Contribution to journal › Article › peer-review

Abstract

CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.

Original language	English
Pages (from-to)	773-776
Number of pages	4
Journal	Infection and Immunity
Volume	74
Issue number	1
DOIs	https://doi.org/10.1128/IAI.74.1.773-776.2006
Publication status	Published - Jan 2006

Keywords

DONOVANI INFECTION
IFN-GAMMA
LYMPHOCYTES
ACTIVATION
AMASTIGOTES
SECRETION
EXPANSION
RESPONSES
EFFECTOR
IMMUNITY

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10.1128/IAI.74.1.773-776.2006

Cite this

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title = "Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen",

abstract = "CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.",

keywords = "DONOVANI INFECTION, IFN-GAMMA, LYMPHOCYTES, ACTIVATION, AMASTIGOTES, SECRETION, EXPANSION, RESPONSES, EFFECTOR, IMMUNITY",

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AU - Polley, R

AU - Stager, S

AU - Prickett, S

AU - Maroof, A

AU - Zubairi, S

AU - Smith, D F

AU - Kaye, P M

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KW - DONOVANI INFECTION

KW - IFN-GAMMA

KW - LYMPHOCYTES

KW - ACTIVATION

KW - AMASTIGOTES

KW - SECRETION

KW - EXPANSION

KW - RESPONSES

KW - EFFECTOR

KW - IMMUNITY

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