Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium

TY - JOUR

T1 - Advanced parental age as risk factor for childhood acute lymphoblastic leukemia

T2 - results from studies of the Childhood Leukemia International Consortium

AU - Petridou, Eleni Th

AU - Georgakis, Marios K

AU - Erdmann, Friederike

AU - Ma, Xiaomei

AU - Heck, Julia E

AU - Auvinen, Anssi

AU - Mueller, Beth A

AU - Spector, Logan G

AU - Roman, Eve

AU - Metayer, Catherine

AU - Magnani, Corrado

AU - Pombo-de-Oliveira, Maria S

AU - Ezzat, Sameera

AU - Scheurer, Michael E

AU - Mora, Ana Maria

AU - Dockerty, John D

AU - Hansen, Johnni

AU - Kang, Alice Y

AU - Wang, Rong

AU - Doody, David R.

AU - Kane, Eleanor

AU - Rashed, Waffa M

AU - Dessypris, Nick

AU - Schüz, Joachim

AU - Infante-Rivard, Claire

AU - Skalkidou, Alkistis

N1 - Could the library team check if this is open source as the whole text is available online.

PY - 2018/10

Y1 - 2018/10

N2 - Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I2 = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.

AB - Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I2 = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.

KW - Acute lymphoblastic leukemia

KW - Case–control

KW - Childhood

KW - Maternal age

KW - Paternal age

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=85053411715&partnerID=8YFLogxK

U2 - 10.1007/s10654-018-0402-z

DO - 10.1007/s10654-018-0402-z

M3 - Article

C2 - 29761423

SN - 0393-2990

VL - 33

SP - 965

EP - 976

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

IS - 10

ER -