Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

Martin J Hoogduijn; Felix C Popp; Anja Grohnert; Meindert J Crop; Marieke van Rhijn; Ajda T Rowshani; Elke Eggenhofer; Philipp Renner; Marlies E Reinders; Ton J Rabelink; Luc J W van der Laan; Frank J M F Dor; Jan N M Ijzermans; Paul G Genever; Claudia Lange; Antoine Durrbach; Jaco H Houtgraaf; Bruno Christ; Martina Seifert; Murat Shagidulin; Vincent Donckier; Robert Deans; Olle Ringden; Norberto Perico; Giuseppe Remuzzi; Amelia Bartholomew; Hans J Schlitt; Willem Weimar; Carla C Baan; Marc H Dahlke; MISOT Study Group

doi:10.1097/TP.0b013e3181ea4240

Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

Martin J Hoogduijn, Felix C Popp, Anja Grohnert, Meindert J Crop, Marieke van Rhijn, Ajda T Rowshani, Elke Eggenhofer, Philipp Renner, Marlies E Reinders, Ton J Rabelink, Luc J W van der Laan, Frank J M F Dor, Jan N M Ijzermans, Paul G Genever, Claudia Lange, Antoine Durrbach, Jaco H Houtgraaf, Bruno Christ, Martina Seifert, Murat ShagidulinVincent Donckier, Robert Deans, Olle Ringden, Norberto Perico, Giuseppe Remuzzi, Amelia Bartholomew, Hans J Schlitt, Willem Weimar, Carla C Baan, Marc H Dahlke, MISOT Study Group

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

Original language	English
Pages (from-to)	124-6
Number of pages	3
Journal	Transplantation
Volume	90
Issue number	2
DOIs	https://doi.org/10.1097/TP.0b013e3181ea4240
Publication status	Published - 27 Jul 2010

Keywords

Cell Culture Techniques
Graft Survival
Humans
Immunophenotyping
Immunosuppression
Kidney Transplantation
Liver Transplantation
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
Organ Transplantation
Safety
T-Lymphocytes
Tissue Therapy

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10.1097/TP.0b013e3181ea4240

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Hoogduijn, M. J., Popp, F. C., Grohnert, A., Crop, M. J., van Rhijn, M., Rowshani, A. T., Eggenhofer, E., Renner, P., Reinders, M. E., Rabelink, T. J., van der Laan, L. J. W., Dor, F. J. M. F., Ijzermans, J. N. M., Genever, P. G., Lange, C., Durrbach, A., Houtgraaf, J. H., Christ, B., Seifert, M., ... MISOT Study Group (2010). Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT). Transplantation, 90(2), 124-6. https://doi.org/10.1097/TP.0b013e3181ea4240

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title = "Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)",

abstract = "There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.",

keywords = "Cell Culture Techniques, Graft Survival, Humans, Immunophenotyping, Immunosuppression, Kidney Transplantation, Liver Transplantation, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Organ Transplantation, Safety, T-Lymphocytes, Tissue Therapy",

author = "Hoogduijn, {Martin J} and Popp, {Felix C} and Anja Grohnert and Crop, {Meindert J} and {van Rhijn}, Marieke and Rowshani, {Ajda T} and Elke Eggenhofer and Philipp Renner and Reinders, {Marlies E} and Rabelink, {Ton J} and {van der Laan}, {Luc J W} and Dor, {Frank J M F} and Ijzermans, {Jan N M} and Genever, {Paul G} and Claudia Lange and Antoine Durrbach and Houtgraaf, {Jaco H} and Bruno Christ and Martina Seifert and Murat Shagidulin and Vincent Donckier and Robert Deans and Olle Ringden and Norberto Perico and Giuseppe Remuzzi and Amelia Bartholomew and Schlitt, {Hans J} and Willem Weimar and Baan, {Carla C} and Dahlke, {Marc H} and {MISOT Study Group}",

year = "2010",

month = jul,

day = "27",

doi = "10.1097/TP.0b013e3181ea4240",

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Hoogduijn, MJ, Popp, FC, Grohnert, A, Crop, MJ, van Rhijn, M, Rowshani, AT, Eggenhofer, E, Renner, P, Reinders, ME, Rabelink, TJ, van der Laan, LJW, Dor, FJMF, Ijzermans, JNM, Genever, PG, Lange, C, Durrbach, A, Houtgraaf, JH, Christ, B, Seifert, M, Shagidulin, M, Donckier, V, Deans, R, Ringden, O, Perico, N, Remuzzi, G, Bartholomew, A, Schlitt, HJ, Weimar, W, Baan, CC, Dahlke, MH & MISOT Study Group 2010, 'Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)', Transplantation, vol. 90, no. 2, pp. 124-6. https://doi.org/10.1097/TP.0b013e3181ea4240

TY - JOUR

T1 - Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

AU - Hoogduijn, Martin J

AU - Popp, Felix C

AU - Grohnert, Anja

AU - Crop, Meindert J

AU - van Rhijn, Marieke

AU - Rowshani, Ajda T

AU - Eggenhofer, Elke

AU - Renner, Philipp

AU - Reinders, Marlies E

AU - Rabelink, Ton J

AU - van der Laan, Luc J W

AU - Dor, Frank J M F

AU - Ijzermans, Jan N M

AU - Genever, Paul G

AU - Lange, Claudia

AU - Durrbach, Antoine

AU - Houtgraaf, Jaco H

AU - Christ, Bruno

AU - Seifert, Martina

AU - Shagidulin, Murat

AU - Donckier, Vincent

AU - Deans, Robert

AU - Ringden, Olle

AU - Perico, Norberto

AU - Remuzzi, Giuseppe

AU - Bartholomew, Amelia

AU - Schlitt, Hans J

AU - Weimar, Willem

AU - Baan, Carla C

AU - Dahlke, Marc H

AU - MISOT Study Group

PY - 2010/7/27

Y1 - 2010/7/27

N2 - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

AB - There is evolving interest in the use of mesenchymal stem cells (MSC) in solid organ transplantation. Pre-clinical transplantation models show efficacy of MSC in prolonging graft survival and a number of clinical studies are planned or underway. At a recent meeting of the MISOT consortium (MSC In Solid Organ Transplantation) the advances of these studies were evaluated and mechanisms underlying the potential effects of MSC discussed. Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation.

KW - Cell Culture Techniques

KW - Graft Survival

KW - Humans

KW - Immunophenotyping

KW - Immunosuppression

KW - Kidney Transplantation

KW - Liver Transplantation

KW - Mesenchymal Stem Cell Transplantation

KW - Mesenchymal Stem Cells

KW - Organ Transplantation

KW - Safety

KW - T-Lymphocytes

KW - Tissue Therapy

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U2 - 10.1097/TP.0b013e3181ea4240

DO - 10.1097/TP.0b013e3181ea4240

M3 - Article

C2 - 20606604

VL - 90

SP - 124

EP - 126

JO - Transplantation

JF - Transplantation

IS - 2

ER -

Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)

Abstract

Keywords

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