TY - JOUR
T1 - Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk
T2 - A Childhood Leukemia International Consortium analysis
AU - FRECCLE group
AU - NARECHEM-ST group
AU - Karalexi, Maria A.
AU - Dessypris, Nick
AU - Ma, Xiaomei
AU - Spector, Logan G.
AU - Marcotte, Erin
AU - Clavel, Jacqueline
AU - Pombo-de-Oliveira, Maria S.
AU - Heck, Julia E.
AU - Roman, Eve
AU - Mueller, Beth A.
AU - Hansen, Johnni
AU - Auvinen, Anssi
AU - Lee, Pei Chen
AU - Schüz, Joachim
AU - Magnani, Corrado
AU - Mora, Ana M.
AU - Dockerty, John D.
AU - Scheurer, Michael E.
AU - Wang, Rong
AU - Bonaventure, Audrey
AU - Kane, Eleanor
AU - Doody, David R.
AU - Baka, Margarita
AU - Moschovi, Maria
AU - Polychronopoulou, Sophia
AU - Kourti, Maria
AU - Hatzipantelis, Emmanuel
AU - Pelagiadis, Iordanis
AU - Dana, Helen
AU - Kantzanou, Maria
AU - Tzanoudaki, Marianna
AU - Anastasiou, Theodora
AU - Grenzelia, Maria
AU - Gavriilaki, Eleni
AU - Sakellari, Ioanna
AU - Anagnostopoulos, Achilles
AU - Kitra, Vassiliki
AU - Paisiou, Anna
AU - Bouka, Evdoxia
AU - Nikkilä, Atte
AU - Lohi, Olli
AU - Erdmann, Friederike
AU - Kang, Alice Y.
AU - Metayer, Catherine
AU - Milne, Elizabeth
AU - Petridou, Eleni Th
N1 - This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged <2 years (OR: 1.34, 95% CI: 1.05–1.71) and 25% in boys aged 0–14 years (OR: 1.25, 95% CI: 1.06–1.46). The association of large for gestational age became stronger in boys with M0/M1subtype (OR: 1.80, 95% CI: 1.15–2.83). Large birth length for gestational age was also positively associated with AML (OR: 1.38, 95% CI: 1.00–1.92) in boys. By contrast, there were null associations in girls, as well as with respect to associations of decelerated foetal growth markers. Conclusions: Accelerated foetal growth was associated with AML, especially in infant boys and those with minimally differentiated leukaemia. Further cytogenetic research would shed light into the underlying mechanisms.
AB - Aim: Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Methods: Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. Results: A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged <2 years (OR: 1.34, 95% CI: 1.05–1.71) and 25% in boys aged 0–14 years (OR: 1.25, 95% CI: 1.06–1.46). The association of large for gestational age became stronger in boys with M0/M1subtype (OR: 1.80, 95% CI: 1.15–2.83). Large birth length for gestational age was also positively associated with AML (OR: 1.38, 95% CI: 1.00–1.92) in boys. By contrast, there were null associations in girls, as well as with respect to associations of decelerated foetal growth markers. Conclusions: Accelerated foetal growth was associated with AML, especially in infant boys and those with minimally differentiated leukaemia. Further cytogenetic research would shed light into the underlying mechanisms.
KW - Acute myeloid leukaemia
KW - Birth length
KW - Birthweight for gestational age
KW - Childhood
KW - Foetal growth
KW - Weight-for-length ratio
UR - http://www.scopus.com/inward/record.url?scp=85081263912&partnerID=8YFLogxK
U2 - 10.1016/j.ejca.2020.01.018
DO - 10.1016/j.ejca.2020.01.018
M3 - Article
C2 - 32163883
AN - SCOPUS:85081263912
SN - 0959-8049
VL - 130
SP - 1
EP - 11
JO - European Journal of Cancer
JF - European Journal of Cancer
ER -
