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From the same journal

Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones: Total Synthesis of Indolizidine 209D

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Publication details

JournalOrganic Letters
DateAccepted/In press - 7 Feb 2018
DateE-pub ahead of print (current) - 9 Feb 2018
Number of pages5
Pages (from-to)1439-1443
Early online date9/02/18
Original languageEnglish


An efficient Ag(I)-catalyzed π-acid activation method for the cyclization of cyclic ketimine-tethered ynones is reported. Various nitrogen-containing scaffolds commonly found in bioactive alkaloids can be prepared in high yields, and the utility of the method is demonstrated by a formal synthesis of (±)-lasubine II and in a short total synthesis of (±)-indolizidine 209D.

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