By the same authors

From the same journal

From the same journal

Allostery in Its Many Disguises: From Theory to Applications

Research output: Contribution to journalReview articlepeer-review

Author(s)

  • Shoshana J Wodak
  • Emanuele Paci
  • Nikolay V Dokholyan
  • Igor N Berezovsky
  • Amnon Horovitz
  • Jing Li
  • Vincent J Hilser
  • Ivet Bahar
  • John Karanicolas
  • Gerhard Stock
  • Peter Hamm
  • Roland H Stote
  • Jerome Eberhardt
  • Yassmine Chebaro
  • Annick Dejaegere
  • Marco Cecchini
  • Jean-Pierre Changeux
  • Peter G Bolhuis
  • Jocelyne Vreede
  • Pietro Faccioli
  • Simone Orioli
  • Riccardo Ravasio
  • Le Yan
  • Carolina Brito
  • Matthieu Wyart
  • Paraskevi Gkeka
  • Ivan Rivalta
  • Giulia Palermo
  • J Andrew McCammon
  • Joanna Panecka-Hofman
  • Rebecca C Wade
  • Antonella Di Pizio
  • Masha Y Niv
  • Ruth Nussinov
  • Chung-Jung Tsai
  • Hyunbum Jang
  • Dzmitry Padhorny
  • Dima Kozakov

Department/unit(s)

Publication details

JournalStructure
DateAccepted/In press - 5 Jan 2019
DateE-pub ahead of print (current) - 7 Feb 2019
Number of pages13
Early online date7/02/19
Original languageEnglish

Abstract

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM (Center Européen de Calcul Atomique et Moléculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.

Bibliographical note

Copyright © 2019. Published by Elsevier Ltd. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy.

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