Alternative splicing of the human PTEN/MMAC1/TEP1 gene

R M Sharrard, N J Maitland

Research output: Contribution to journalArticlepeer-review

Abstract

The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns. (C) 2000 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalBiochimica et biophysica acta-Gene structure and expression
Volume1494
Issue number3
Publication statusPublished - 1 Dec 2000

Keywords

  • PTEN/MMAC1/TEP1
  • alternative splicing
  • reverse transcriptase polymerase chain reaction
  • phosphatase
  • TUMOR-SUPPRESSOR GENE
  • PHOSPHATASE-ACTIVITY
  • PROSTATE-CANCER
  • GLIOMA-CELLS
  • PTEN
  • MUTATION
  • PROTEIN
  • FREQUENT
  • IDENTIFICATION
  • EXPRESSION

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