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Alternative splicing of the human PTEN/MMAC1/TEP1 gene

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JournalBiochimica et biophysica acta-Gene structure and expression
DatePublished - 1 Dec 2000
Issue number3
Volume1494
Number of pages4
Pages (from-to)282-285
Original languageEnglish

Abstract

The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns. (C) 2000 Elsevier Science B.V. All rights reserved.

    Research areas

  • PTEN/MMAC1/TEP1, alternative splicing, reverse transcriptase polymerase chain reaction, phosphatase, TUMOR-SUPPRESSOR GENE, PHOSPHATASE-ACTIVITY, PROSTATE-CANCER, GLIOMA-CELLS, PTEN, MUTATION, PROTEIN, FREQUENT, IDENTIFICATION, EXPRESSION

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