Amino Imidate-Catalyzed Asymmetric Michael Reactions of Ketones and Nitroalkenes

Paul Andrew Clarke, Bohdan Sosunovych, Alexander Brown

Research output: Contribution to journalArticlepeer-review


The efficiency of an amino imidate organocatalyst was evaluated in the Michael reaction of ketones with nitroalkenes. tert-Butyl L-proline imidate was found to be a syn-selective catalyst generating products with moderate to good enantioselectivities, of up to 84% e.e. The best substrates were found to be cyclic ketones and -nitrostyrenes. The catalytic efficiency and enantioselectivity was enhanced by the addition of 10 mol% of benzoic acid.
Original languageEnglish
Article numberSO-2022-01-0005-OP.R1
Pages (from-to)67-74
Number of pages8
Early online date4 Feb 2022
Publication statusPublished - 24 Feb 2022

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