Projects per year
Abstract
The efficiency of an amino imidate organocatalyst was evaluated in the Michael reaction of ketones with nitroalkenes. tert-Butyl L-proline imidate was found to be a syn-selective catalyst generating products with moderate to good enantioselectivities, of up to 84% e.e. The best substrates were found to be cyclic ketones and -nitrostyrenes. The catalytic efficiency and enantioselectivity was enhanced by the addition of 10 mol% of benzoic acid.
Original language | English |
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Article number | SO-2022-01-0005-OP.R1 |
Pages (from-to) | 67-74 |
Number of pages | 8 |
Journal | SynOpen |
Volume | 6 |
Early online date | 4 Feb 2022 |
DOIs | |
Publication status | Published - 24 Feb 2022 |
Projects
- 1 Finished
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Investigating the use of Amino nitriles and Amino imidates as organocatalysts
Clarke, P. A. (Principal investigator), Vagkidis, N. (Student) & Sosunovych, B. (Student)
1/10/17 → 30/04/22
Project: Other project › Miscellaneous project
Datasets
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Aminoimidate Catalysed Michael Addition of Carbonyl Compounds to Nitroalkenes
Clarke, P. A. (Creator), Sosunovych, B. (Contributor) & Brown, A. (Contributor), University of York, 1 Oct 2021
DOI: 10.15124/207e9639-5f06-4eea-af9c-4ded13054afa
Dataset