An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

Françoise Bachelerie; Gerard J. Graham; Massimo Locati; Alberto Mantovani; Philip M. Murphy; Robert Nibbs; Antal Rot; Silvano Sozzani; Marcus Thelen

doi:10.1111/bph.13182

An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

Françoise Bachelerie, Gerard J. Graham^*, Massimo Locati, Alberto Mantovani, Philip M. Murphy, Robert Nibbs, Antal Rot, Silvano Sozzani, Marcus Thelen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Chemokines and their receptors are essential regulators of in vivo leukocyte migration and, some years ago, a systematic nomenclature system was developed for the chemokine receptor family. Chemokine receptor biology and biochemistry was recently extensively reviewed. In this review, we also highlighted a new component to the nomenclature system that incorporates receptors previously known as 'scavenging', or 'decoy', chemokine receptors on the basis of their lack of classical signalling responses to ligand binding and their general ability to scavenge, or sequester, their cognate chemokine ligands. These molecules are now collectively referred to as 'atypical chemokine receptors', or ACKRs, and play fundamental roles in regulating in vivo responses to chemokines. This commentary highlights this new addition to the chemokine receptor nomenclature system and provides brief information on the four receptors currently covered by this nomenclature.

Original language	English
Pages (from-to)	3945-3949
Number of pages	5
Journal	BRITISH JOURNAL OF PHARMACOLOGY
Volume	172
Issue number	16
DOIs	https://doi.org/10.1111/bph.13182
Publication status	Published - 26 Jun 2015

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AU - Murphy, Philip M.

AU - Nibbs, Robert

AU - Rot, Antal

AU - Sozzani, Silvano

AU - Thelen, Marcus

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An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15

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