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Journal | Chemical Communications |
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Date | Accepted/In press - 27 Jul 2017 |
Date | E-pub ahead of print - 28 Jul 2017 |
Date | Published (current) - 25 Aug 2017 |
Issue number | 66 |
Volume | 53 |
Number of pages | 4 |
Pages (from-to) | 9238-9241 |
Early online date | 28/07/17 |
Original language | English |
The non-hydrolyzable S-linked azasugars, 1,6-α-mannosylthio- and 1,6-α-mannobiosylthioisofagomine, were synthesized and shown to bind with high affinity to a family 76 endo-1,6-α-mannanase from Bacillus circulans. X-ray crystallography showed an atypical interaction of the isofagomine nitrogen with the catalytic acid/base. Molecular dynamics simulations reveal that the atypical binding results from sulfur perturbing the most stable form away from the nucleophile interaction preferred for the O-linked congener.
©The Royal Society of Chemistry 2017. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Project: Research project (funded) › Research
Project: Research project (funded) › Research
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