An eco-friendly paradigm for the synthesis of α-hydroxyphosphonates using sodium-modified fluorapatite under solventless conditions

Hugo Ronald Ramananarivo, Abderrahim Solhy*, Jalila Sebti, Abedlatif Smahi, Mohamed Zahouily, James Clark, Said Sebti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A versatile and environmentally friendly method for the synthesis of various organophosphorus compounds have been developed using a heterogeneous catalysis technology. We have synthesized a series of the α- hydroxyphosphonates, a biologically important class of compounds, via the Pudovik reaction between dialkylphosphite and aldehydes or ketones using sodium-modified fluorapatite (Na@FAP) as a highly efficient basic solid catalyst under solventless conditions at room temperature. Catalyst reuse, ease of separation of the pure product, and high yields are some of the unique features of this process.

Original languageEnglish
Pages (from-to)403-409
Number of pages7
JournalACS Sustainable Chemistry and Engineering
Issue number4
Publication statusPublished - 1 Apr 2013


  • α-Hydroxyphosphonates
  • Fluorapatite
  • Green Synthesis
  • Heterogeneous catalysis
  • Sodium-modified fluorapatite
  • Without solvent

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