An efficient and extremely mild method for protecting alcohols as 2-tetrahydrofuranyl ethers

J M Barks, B C Gilbert, A F Parsons, B Upeandran

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Reaction of primary or secondary alcohols with BrCCl3 and tetrahydrofuran, usually in the presence of 2,4,6-collidine, leads to the formation of 2-tetrahydrofuranyl ethers in good to excellent yield (56-92%). The reaction mechanism is believed to involve a free-radical chain reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)6249-6252
Number of pages4
JournalTetrahedron Letters
Issue number32
Publication statusPublished - 5 Aug 2000


  • acetals
  • protecting groups
  • radicals and radical reactions
  • oxygen heterocycles

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