By the same authors

From the same journal

From the same journal

An evaluation of credentials of a multicomponent reaction for the synthesis of isothioureas through the use of a holistic CHEM21 green metrics toolkit

Research output: Contribution to journalArticlepeer-review

Full text download(s)

Published copy (DOI)


  • S. Abou-Shehada
  • P. Mampuys
  • B. U.W. Maes
  • J. H. Clark
  • L. Summerton


Publication details

JournalGreen Chemistry
DateAccepted/In press - 6 Oct 2016
DateE-pub ahead of print - 7 Oct 2016
DatePublished (current) - 7 Jan 2017
Issue number1
Number of pages10
Pages (from-to)249-258
Early online date7/10/16
Original languageEnglish


Multicomponent reactions (MCRs) are considered green and material efficient methods for the synthesis of organic compounds, however very few studies have investigated the metrics of the upstream processes involved to achieve the starting materials used in these reactions. A novel MCR-approach for the synthesis of N-cyclohexyl-S-methyl-N′-phenylisothiourea from S-methyl methanethiosulfonate, cyclohexyl isocyanide and aniline was appraised in terms of its green metrics using the CHEM21 green metrics toolkit and compared with those of the state of the art approach. The upstream process leading to the component starting materials for both approaches were also appraised to gain an insight into how the greenness of both methods translate from the raw materials to the final product.

Bibliographical note

© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations