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MCRmetrics paper_Maes_Summerton_revised_Sept2016_PM_BM_no comments
6.12 MB, Word document
Journal | Green Chemistry |
---|---|
Date | Accepted/In press - 6 Oct 2016 |
Date | E-pub ahead of print - 7 Oct 2016 |
Date | Published (current) - 7 Jan 2017 |
Issue number | 1 |
Volume | 19 |
Number of pages | 10 |
Pages (from-to) | 249-258 |
Early online date | 7/10/16 |
Original language | English |
Multicomponent reactions (MCRs) are considered green and material efficient methods for the synthesis of organic compounds, however very few studies have investigated the metrics of the upstream processes involved to achieve the starting materials used in these reactions. A novel MCR-approach for the synthesis of N-cyclohexyl-S-methyl-N′-phenylisothiourea from S-methyl methanethiosulfonate, cyclohexyl isocyanide and aniline was appraised in terms of its green metrics using the CHEM21 green metrics toolkit and compared with those of the state of the art approach. The upstream process leading to the component starting materials for both approaches were also appraised to gain an insight into how the greenness of both methods translate from the raw materials to the final product.
© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.
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