An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine

TY - JOUR

T1 - An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine

AU - Unsworth, William P

AU - Kitsiou, Christiana

AU - Taylor, Richard J K

PY - 2013/6/20

Y1 - 2013/6/20

N2 - The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis.

AB - The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis.

U2 - 10.1021/ol4013469

DO - 10.1021/ol4013469

M3 - Article

C2 - 23786450

SN - 1523-7060

VL - 15

SP - 3302

EP - 3305

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -