An Expedient Protecting-Group-Free Total Synthesis of (±)-Dievodiamine

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The first total synthesis of the Evodia rutaecarpa derived natural product dievodiamine is described. The convergent synthesis was performed without protecting groups, delivering a route that is short and high yielding and uses limited chromatography. Key steps include organometallic addition into a DHED adduct and the Stille coupling of two advanced intermediates to complete the synthesis.
Original languageEnglish
Pages (from-to)3302-3305
JournalOrganic Letters
Issue number13
Publication statusPublished - 20 Jun 2013

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